Cbz-D-Cys(α-D-GlcNAc)-OH | 1533407-90-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Cbz-D-Cys(α-D-GlcNAc)-OH
• CAS: 1533407-90-7
• 化学式: C₁₉H₂₆N₂O₉S
• 分子量: 458.489
• InChiKey: KBSXHWLQIQNQGH-KRIAZEKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.96
• 重原子数：
  31.0
• 可旋转键数：
  9.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  174.65
• 氢给体数：
  6.0
• 氢受体数：
  9.0

反应信息

• 作为反应物：
  描述：

  Cbz-D-Cys(α-D-GlcNAc)-OH 在 吡啶 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 S-((tri-O-acetyl)-2-acetamido-2-deoxy-α-D-glucosyl)-N-Cbz-D-cysteine benzyl ester
  参考文献：
  名称：

  S-Michael Additions to Chiral Dehydroalanines as an Entry to Glycosylated Cysteines and a Sulfa-Tn Antigen Mimic

  摘要：

  Stereoselective sulfa-Michael addition of appropriately protected thiocarbohydrates to chiral dehydroalanines has been developed as a key step in the synthesis of biologically important cysteine derivatives, such as S-(beta-D-glucopyranosyl)-D-cysteine, which has not been synthesized to date, and S-(2-acetamido-2-deoxy-alpha-D-galactopyranosyl)-L-cysteine, which could be considered as a mimic of Tn antigen. The corresponding diamide derivative was also synthesized and analyzed from a conformational viewpoint, and its bound state with a lectin was studied.

  DOI：

  10.1021/ja411522f
• 作为产物：
  描述：

  S-(2-acetamido-2-deoxy-α-D-glucosyl)-D-cysteine hydrochloride 、 氯甲酸苄酯 在 碳酸氢钠 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以29%的产率得到Cbz-D-Cys(α-D-GlcNAc)-OH
  参考文献：
  名称：

  S-Michael Additions to Chiral Dehydroalanines as an Entry to Glycosylated Cysteines and a Sulfa-Tn Antigen Mimic

  摘要：

  Stereoselective sulfa-Michael addition of appropriately protected thiocarbohydrates to chiral dehydroalanines has been developed as a key step in the synthesis of biologically important cysteine derivatives, such as S-(beta-D-glucopyranosyl)-D-cysteine, which has not been synthesized to date, and S-(2-acetamido-2-deoxy-alpha-D-galactopyranosyl)-L-cysteine, which could be considered as a mimic of Tn antigen. The corresponding diamide derivative was also synthesized and analyzed from a conformational viewpoint, and its bound state with a lectin was studied.

  DOI：

  10.1021/ja411522f