2,5-anhydro-3,4-di-O-benzyl-1-deoxy-1-(3'-(N-tert-butyloxycarbonyl)uracil-1'-yl)-6-(5''-(N,N',N'',N''-tetra-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol | 1237748-07-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-anhydro-3,4-di-O-benzyl-1-deoxy-1-(3'-(N-tert-butyloxycarbonyl)uracil-1'-yl)-6-(5''-(N,N',N'',N''-tetra-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol
• CAS: 1237748-07-0
• 化学式: C₆₀H₈₅N₅O₁₉
• 分子量: 1180.36
• InChiKey: OTXKNJPWBZEFEJ-QXQUBIHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.47
• 重原子数：
  84.0
• 可旋转键数：
  15.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  258.95
• 氢给体数：
  0.0
• 氢受体数：
  21.0

反应信息

• 作为反应物：
  描述：

  2,5-anhydro-3,4-di-O-benzyl-1-deoxy-1-(3'-(N-tert-butyloxycarbonyl)uracil-1'-yl)-6-(5''-(N,N',N'',N''-tetra-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以99%的产率得到2,5-anhydro-1-deoxy-1-(3'-(N-tert-butyloxycarbonyl)uracil-1'-yl)-6-(5''-(N,N',N'',N''-tetra-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol
  参考文献：
  名称：

  Bacterial transferase MraY inhibitors: Synthesis and biological evaluation

  摘要：

  New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.04.023
• 作为产物：
  描述：

  二碳酸二叔丁酯 、 2,5-anhydro-3,4-di-O-benzyl-1-deoxy-1-(uracil-1'-yl)-6-(5''-(N,N'-bis-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以92%的产率得到2,5-anhydro-3,4-di-O-benzyl-1-deoxy-1-(3'-(N-tert-butyloxycarbonyl)uracil-1'-yl)-6-(5''-(N,N',N'',N''-tetra-(tert-butyloxycarbonyl)guanidino)-1'',5''-dideoxy-2'',3''-O-isopentylidene-β-D-ribos-1''-yl)-D-glucitol
  参考文献：
  名称：

  Bacterial transferase MraY inhibitors: Synthesis and biological evaluation

  摘要：

  New inhibitors of the bacterial transferase MraY are described. Their structure is based on an aminoribosyl-O-uridine like scaffold, readily obtained in two key steps. The amino group can be coupled with proline or guanylated. Alternatively, these amino, prolinyl or guanidinyl groups can be introduced through a triazole linker. Biological evaluation of these compounds on MraY from Bacillus subtilis revealed interesting inhibitory activity for both amino compounds. (C) 2010 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2010.04.023