(R)-4-O-<2'-(trimethylsilyl)eth-1'-oxymethyl>butane-1,2,4-triol | 159424-43-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-4-O-<2'-(trimethylsilyl)eth-1'-oxymethyl>butane-1,2,4-triol
• CAS: 159424-43-8
• 化学式: C₁₀H₂₄O₄Si
• 分子量: 236.384
• InChiKey: CJTGMWQQJLSSLG-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.06
• 重原子数：
  15.0
• 可旋转键数：
  9.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.92
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  (R)-4-O-<2'-(trimethylsilyl)eth-1'-oxymethyl>butane-1,2,4-triol 在 吡啶 、 lithium 作用下， 反应 2.0h， 生成
  参考文献：
  名称：

  Synthesis and catalytic properties of an acyclic analogue of hydroxy norphos

  摘要：

  The synthesis of (S)-1,2-bis(diphenylphosphino)butane-4-ol 1 an acyclic analogue of hydroxy norphos is described, starting from L-ascorbic acid. Problems which arose during the cleavage of OH-protective groups in the presence of phosphino groups are discussed. The hydrogenation properties of the catalyst derived from the new ligand are compared with those obtained with hydroxy norphos.(1)

  DOI：

  10.1016/s0040-4020(01)89582-x
• 作为产物：
  描述：

  (R)-1,2-O-isopropylidene-4-O-<2'-(trimethylsilyl)eth-1'-oxymethyl>butane-1,2,4-triol 在 溶剂黄146 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 4.0h， 生成 (R)-4-O-<2'-(trimethylsilyl)eth-1'-oxymethyl>butane-1,2,4-triol
  参考文献：
  名称：

  Synthesis and catalytic properties of an acyclic analogue of hydroxy norphos

  摘要：

  The synthesis of (S)-1,2-bis(diphenylphosphino)butane-4-ol 1 an acyclic analogue of hydroxy norphos is described, starting from L-ascorbic acid. Problems which arose during the cleavage of OH-protective groups in the presence of phosphino groups are discussed. The hydrogenation properties of the catalyst derived from the new ligand are compared with those obtained with hydroxy norphos.(1)

  DOI：

  10.1016/s0040-4020(01)89582-x