6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one | 1161924-88-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one
• CAS: 1161924-88-4
• 化学式: C₁₈H₁₄F₈N₂O
• 分子量: 426.309
• InChiKey: WSYPOMVUDHNQQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.46
• 重原子数：
  29.0
• 可旋转键数：
  3.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  34.89
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one 在 N-溴代丁二酰亚胺(NBS) 、 sodium azide 、 copper(ll) sulfate pentahydrate 、 铜 作用下， 以 四氯化碳 、 水 、 丙酮 、 叔丁醇 为溶剂， 反应 64.0h， 生成 1-(4-fluorophenyl)-6,6-dimethyl-3-perfluoropropyl-7-(4-phenyl-1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-one
  参考文献：
  名称：

  Regioselective synthesis of polyfluoroalkyl-substituted 7-(1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-ones

  摘要：

  3-Polyfluoroalkyl-6,6-dimethyl-7-(1H-1,2,3-triazol-1-yl)-6,7-dihydro-1H-indazol-4(5H)-ones were synthesized with high regioselectivity by 1,3-dipolar cycloaddition of terminal alkynes (phenylacetylene, hex-1-yne, hept-1-yne, and but-3-yn-1-ol) to 7-azido-6,6-dimethyl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol-4(5H)-ones which were prepared by bromination of 6,6-dimethyl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol-4(5H)-ones with N-bromosuccinimide in anhydrous carbon tetrachloride, followed by treatment of the corresponding 7-bromo derivatives with sodium azide.

  DOI：

  10.1134/s1070428012030128
• 作为产物：
  描述：

  2-heptafluorobutyryl-5,5-dimethylcyclohexane-1,3-dione 、 4-氟苯肼盐酸盐 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以71%的产率得到6,6-dimethyl-3-perfluoropropyl-1-(4-fluorophenyl)-6,7-dihydro-1H-indazol-4(5H)-one
  参考文献：
  名称：

  Synthesis and spectroscopic investigation of the new polyfluoroalkyl-containing indazolones

  摘要：

  Reaction of 2-perfluoroacylcycloalkane-1,3-diones and their enol methyl esters with N,N-dinucleophiles such as 4-fluorophenylhydrazine hydrochloride and pentafluorophenylhydrazine results in formation of polyfluoroalkyl-containing 1-aryl-3-polyfluoroalkyl-6,7-dihydro-1H-indazol-4(5)H-ones and 2-aryl-3-polyfluoroalkyl-6,7-dihydro-2H-indazol-4(5)H-ones respectively. Structure of compounds obtained was proved with IR, H-1, H-13, F-19, N-15 NMR, and mass-spectrometric methods.

  DOI：

  10.1134/s1070363208100241

文献信息

• Synthesis of perfluoroalkyl-substituted 4,5-dihydro-3H-pyrazolo[4,3-a]phenazines and tetrahydroimidazo[4,5-e]indazoles
  作者：T. S. Khlebnikova、Yu. A. Piven’、A. V. Baranovskii、F. A. Lakhvich

  DOI：10.1134/s1070428013030184

  日期：2013.3

  Oxidation of 1-aryl-3-perfluoroalkyl-6,7-dihydro-1H-indazol-4(5H)-ones with selenium dioxide in the presence of sulfuric acid in glacial acetic acid, followed by treatment of 6,7-dihydro-1H-indazole-4,5-diones thus obtained with an equimolar amount of o-phenylenediamine in ethanol or with a mixture of 4-fluorobenzaldehyde and ammonium acetate in acetic acid, gave 3-aryl-1-perfluoroalkyl-4,5-dihydro-3H-pyrazolo-[4

  在冰醋酸中有硫酸存在下，用二氧化硒氧化1-芳基-3-全氟烷基-6,7-二氢-1 H-吲唑-4（5 H）-ones，然后处理6,7-用乙醇中等摩尔量的邻苯二胺或乙酸中4-氟苯甲醛和乙酸铵的混合物制得二氢-1 H-吲唑-4,5-二酮，得到3-芳基-1-全氟烷基-4， 5-二氢-3 H-吡唑并-[4,3- a ]吩嗪和6-芳基-2-（4-氟苯基）-8-全氟烷基-1（3），4,5,6-四氢咪唑并[4,5 - ë ]吲唑，分别。
• Synthesis of novel lupane triterpenoid-indazolone hybrids with oxime ester linkage
  作者：Tatyana S. Khlebnicova、Yuri A. Piven、Alexander V. Baranovsky、Fedor A. Lakhvich、Svetlana V. Shishkina、Daina Zicāne、Zenta Tetere、Irisa Rāviņa、Viktors Kumpiņš、Inese Rijkure、Inese Mieriņa、Uldis Peipiņš、Māris Turks

  DOI：10.1016/j.steroids.2016.08.002

  日期：2017.1

  An efficient protocol for the synthesis of novel lupane triterpenoid-indazolone hybrids with oxime ester linkage has been developed from naturally accessible precursor betulin. For the first time a series of betulonic acid-indazolone hybrids have been synthesized via an acylation of corresponding 6,7-dihydro-1H-indazol-4(5H)-one oximes with betulonic acid chloride. Diastereoselective reduction of the obtained betulonic acid conjugates with NaBH4 resulted in a formation of betulinic acid-indazolone hybrids in excellent yields. The configuration of the key compounds has been fully established by X-ray and 2D NMR analysis. (C) 2016 Elsevier Inc. All rights reserved.
• Synthesis and transformations of perfluoroalkyl-containing 6,7-dihydro-1H-indazol-4(5H)-ones oximes
  作者：T. S. Khlebnikova、Yu. A. Piven’、A. V. Baranovskii、F. A. Lakhvich

  DOI：10.1134/s1070428015050115

  日期：2015.5

  Refluxing 3-perfluoroalkyl-6,7-dihydro-1H-indazol-4(5H)-ones with 4-fold excess of hydroxylamine hydrochloride in pyridine afforded their (E)-oximes. The obtained oximes were alkylated with ethyl iodide and acylated with carboxylic acids chlorides to obtain (E)-O-alkyl- and (E)-O-acyloximes respectively. Heating oximes in PPA at 120A degrees C results in their aromatization by Semmler-Wolff reaction, hydrolysis of perfluoroalkyl groups, and generation of 4-amino-1-aryl-5,6-dimethyl-1H-indazole-3-carboxylic acids from of 3-tri-fluoromethylindazolone oximes and 1-(4-amino-1-aryl-5,6-dimethyl-1H-indazol-3-yl)-fluoroalkan-1-ones from of 3-perfluoroethyl- and 3-perfluoropropylindazolone oximes.