5,8-di-O-acetyl-3,7-anhydro-1-C-bromo-1,2,6-trideoxy-6-C-<<<1,1-dimethyl-3-<(triisopropylsilyl)oxy>propyl>dimethylsilyl>ethynyl>-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol | 221662-92-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 5,8-di-O-acetyl-3,7-anhydro-1-C-bromo-1,2,6-trideoxy-6-C-<<<1,1-dimethyl-3-<(triisopropylsilyl)oxy>propyl>dimethylsilyl>ethynyl>-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol
• CAS: 221662-92-6
• 化学式: C₃₉H₇₁BrO₇Si₃
• 分子量: 816.149
• InChiKey: UBORVBJHBNGXBF-LTBFCVEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.39
• 重原子数：
  50.0
• 可旋转键数：
  16.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  80.29
• 氢给体数：
  0.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  5,8-di-O-acetyl-3,7-anhydro-1,2,6-trideoxy-6-C-ethynyl-4-O-(triisopropylsilyl)-1-C-(trimethylsilyl)-D-glycero-D-gulo-oct-1-ynitol 、 5,8-di-O-acetyl-3,7-anhydro-1-C-bromo-1,2,6-trideoxy-6-C-<<<1,1-dimethyl-3-<(triisopropylsilyl)oxy>propyl>dimethylsilyl>ethynyl>-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol 在 tris-(dibenzylideneacetone)dipalladium(0) 、 copper(l) iodide 、 P(fur)3 、 三乙胺 作用下， 以 二甲基亚砜 为溶剂， 反应 18.0h， 以34%的产率得到7,10-di-O-acetyl-5,9-anhydro-1,2,3,4,8-pentadeoxy-8-C-<<<1,1,-dimethyl-3-<(triisopropylsilyl)oxy>propyl>dimethylsilyl>ethynyl>-6-O-(triisopropylsilyl)-D-glycero-D-gulo-deca-1,3-diynitol-1-yl-(1->6-C)-5,8-di-O-acetyl-3,7-anhydro-1,2,6-trideoxy-4-O-(tr...
  参考文献：
  名称：

  Oligosaccharide Analogues of Polysaccharides, Part 17, Synthesis and Characterization of a Hexadecamer: Evidence for the Essential Structural Role of the Intramolecular, Interresidue C(3)−OH⋅⋅⋅O−C(5) Hydrogen Bond in Celluloses

  摘要：

  The hexadecamer 63 dissolves readily in DMSO and shows no sign of association, in agreement with the essential structural role of the intramolecular, interresidue C(3)-OH ... O-C(5) H-bond of celluloses, MM3 Calculations predict a rod-like shape for the cello-oligosaccharides In agreement with this, nanocrystalline domains of parallel chains are observed by high-resolution electron microscopy (HREM) for 54 and 63 on carbon-coated copper grids. For the synthesis of the hexadecamer 54, we studied the influence of protecting groups on the cross-coupling of acetyleno-oligosaccharides and on their solubility (Scheme 2). The octamer 12 derived from the minimally O-protected monomer 2 is insoluble, while the methoxymethyl- and triisopropysilyl-protected hexadecamer 54 prepared in twelve steps from the dimer 41 (Scheme 4), is readily soluble in a variety of solvents. O- and C-deprotection of 54 led in four steps and in 76% yield to the hexadecamer 63 (Schemes 5 and 6). There is only a small difference of spectroscopic properties between the protected octamer 50 and hexadecamer 54, and, similarly, between the unprotected octamer 64 and hexadecamer 63 (Fig. 3).

  DOI：

  10.1002/(sici)1522-2675(19990210)82:2<198::aid-hlca198>3.0.co;2-y
• 作为产物：
  描述：

  乙酸酐 、 3,7-anhydro-1-C-bromo-1,2,6-trideoxy-6-C-<propyl>silyl>ethynyl>-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol 在 吡啶 、 4-二甲氨基吡啶 作用下， 反应 35.0h， 以89%的产率得到5,8-di-O-acetyl-3,7-anhydro-1-C-bromo-1,2,6-trideoxy-6-C-<<<1,1-dimethyl-3-<(triisopropylsilyl)oxy>propyl>dimethylsilyl>ethynyl>-4-O-(triisopropylsilyl)-D-glycero-D-gulo-oct-1-ynitol
  参考文献：
  名称：

  Oligosaccharide Analogues of Polysaccharides, Part 17, Synthesis and Characterization of a Hexadecamer: Evidence for the Essential Structural Role of the Intramolecular, Interresidue C(3)−OH⋅⋅⋅O−C(5) Hydrogen Bond in Celluloses

  摘要：

  The hexadecamer 63 dissolves readily in DMSO and shows no sign of association, in agreement with the essential structural role of the intramolecular, interresidue C(3)-OH ... O-C(5) H-bond of celluloses, MM3 Calculations predict a rod-like shape for the cello-oligosaccharides In agreement with this, nanocrystalline domains of parallel chains are observed by high-resolution electron microscopy (HREM) for 54 and 63 on carbon-coated copper grids. For the synthesis of the hexadecamer 54, we studied the influence of protecting groups on the cross-coupling of acetyleno-oligosaccharides and on their solubility (Scheme 2). The octamer 12 derived from the minimally O-protected monomer 2 is insoluble, while the methoxymethyl- and triisopropysilyl-protected hexadecamer 54 prepared in twelve steps from the dimer 41 (Scheme 4), is readily soluble in a variety of solvents. O- and C-deprotection of 54 led in four steps and in 76% yield to the hexadecamer 63 (Schemes 5 and 6). There is only a small difference of spectroscopic properties between the protected octamer 50 and hexadecamer 54, and, similarly, between the unprotected octamer 64 and hexadecamer 63 (Fig. 3).

  DOI：

  10.1002/(sici)1522-2675(19990210)82:2<198::aid-hlca198>3.0.co;2-y