1-(2,6-dichloro-5-ethyl-pyridin-3-yl)-2-ethyl-butan-1-one | 848949-31-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,6-dichloro-5-ethyl-pyridin-3-yl)-2-ethyl-butan-1-one
• 英文别名: 1-(2,6-dichloro-5-ethylpyridin-3-yl)-2-ethylbutan-1-one
• CAS: 848949-31-5
• 化学式: C₁₃H₁₇Cl₂NO
• 分子量: 274.19
• InChiKey: LHBQVBVCWLHKAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2,6-dichloro-5-ethyl-pyridin-3-yl)-2-ethyl-butan-1-one 、 甲基肼 在 silica gel 作用下， 生成 6-chloro-5-ethyl-3-(1-ethyl-propyl)-1-methyl-1H-pyrazolo[3,4-b]pyridine
  参考文献：
  名称：

  5-Aryl-pyrazolo[4,3-d]pyrimidines, pyridines, and pyrazines and related compounds

  摘要：

  本发明提供了5-芳基吡唑并[4,3-d]嘧啶、6-芳基吡唑并[3,4-d]嘧啶及其相关化合物，以及其他化学相关化合物，它们作为选择性CRF1受体调节剂。这些化合物在治疗许多中枢神经系统和周围疾病，特别是压力、焦虑、抑郁、心血管疾病和进食障碍方面非常有用。本发明还提供了治疗这些疾病的方法以及包装的制药组合物。本发明的化合物还可用作CRF受体定位的探针和CRF受体结合测定的标准。本发明还提供了使用这些化合物进行受体定位研究的方法。

  公开号：

  US20050070542A1

文献信息

• Ethylenic copolymer, composition containing said copolymer, and ethylenic copolymer film
  申请人：Idemitsu Kosan Co., Ltd.

  公开号：US20020188087A1

  公开（公告）日：2002-12-12

  Disclosed is an ethylenic copolymer having Mw/Mn, as measured through GPC, of from 1.5 to 4, Mw of from 3,000 to 1,000,000, and a resin density of from 0.85 and 0.95 g/cm 3 . The relationship between the half width at the half maximum [W/2] of the curve as obtained through Gaussian distribution approximation relative to the essential peak of the compositional distribution curve of the copolymer obtained through temperature rising elution fractionation analysis, and the average, n, of short-chain branches existing in the copolymer satisfies an equation, 0.704+0.147n ≦W/2≦−0.055+0.577n. Also disclosed is an ethylenic copolymer having Mw/Mn of from 1.5 to 4 and a resin density of from 0.85 and 0.95 g/cm 3 . The tear strength (TS, kgf/cm) of the copolymer satisfies equations, TS ≧131.5−155×log[{( B+C+D )/ A }+0.1], and 0.1≦( B+C+D )/ A ≦1. In these, A indicates the area of the range surrounded by the curve as obtained through the Gaussian distribution approximation, and the base line of the compositional distribution curve; B indicates the area of the range surrounded by the compositional distribution curve, the curve obtained through Gaussian distribution approximation, and the base line, the area of B being in the lower elution temperature side and being at an elution temperature higher than 32° C., while C indicates the area of the range surrounded by these three and falling in the higher elution temperature side; and D indicates the area of the range surrounded by the compositional distribution curve and the base line and falling within at an elution temperature range between 25 and 32° C. Further disclosed is an ethylenic copolymer composition comprising any of such ethylenic copolymers. The ethylenic copolymers have a narrow molecular weight distribution and a narrow branching degree distribution while having a controlled compositional distribution profile, and therefore can be formed into films having good mechanical characteristics including tear strength and impact strength and having good heat-sealing properties and high ESCR (environmental stress crack resistance).

  本发明公开了一种乙烯共聚物，通过 GPC 测量，其 Mw/Mn 为 1.5 至 4，Mw 为 3,000 至 1,000,000，树脂密度为 0.85 至 0.95 克/厘米 3。 3 .通过高斯分布近似法得到的共聚物成分分布曲线相对于升温洗脱分馏分析得到的共聚物成分分布曲线的主峰的半最大宽度[W/2]与共聚物中存在的短链分支的平均值 n 之间的关系满足等式 0.704+0.147n≦W/2≦-0.055+0.577n。还公开了一种乙烯共聚物，其 Mw/Mn 为 1.5 至 4，树脂密度为 0.85 至 0.95 g/cm3 3 .该共聚物的抗撕裂强度（TS，kgf/cm）满足以下公式、 撕裂强度 ≧131.5−155×log[{( B+C+D )/ A }+0.1]、 和 0.1≦( B+C+D )/ A ≦1。 其中，A 表示通过高斯分布近似得到的曲线和成分分布曲线基线所包围的范围的面积；B 表示成分分布曲线、通过高斯分布近似得到的曲线和基线所包围的范围的面积，B 的面积位于洗脱温度较低的一侧，且洗脱温度高于 32 摄氏度、进一步公开的是一种乙烯共聚物组合物，包含上述任何一种乙烯共聚物。这种乙烯共聚物具有窄分子量分布和窄支化度分布，同时具有受控的成分分布曲线，因此可以形成具有良好机械特性（包括撕裂强度和冲击强度）的薄膜，并具有良好的热封性能和高ESCR（耐环境应力开裂性）。
• 5-ARYL-PYRAZOLO [4,3-D] PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS
  申请人：NEUROGEN CORPORATION

  公开号：EP1675858A2

  公开（公告）日：2006-07-05
• US6441116B1
  申请人：——

  公开号：US6441116B1

  公开（公告）日：2002-08-27
• US6844398B2
  申请人：——

  公开号：US6844398B2

  公开（公告）日：2005-01-18
• [EN] 5-ARYL-PYRAZOLO[4,3-D]PYRIMIDINES, PYRIDINES, AND PYRAZINES AND RELATED COMPOUNDS<br/>[FR] 5-ARYL-PYRAZOLO[4,3-D]PYRIMIDINES, PYRIDINES, ET PYRAZINES ET COMPOSES ASSOCIES
  申请人：NEUROGEN CORP

  公开号：WO2005028480A2

  公开（公告）日：2005-03-31

  5-aryl-Pyrazolo[4,3-d] pyrimidines, 6-aryl-Pyrazolo[3,4-d]pyrimidines and related compounds, as well as other chemically related compounds, that act as selective modulators of CRF 1 receptors are provided. These compounds are useful in the treatment of a number of CNS and periphereal disorders, particularly stress, anxiety, depression, cardiovascular disorders, and eating disorders. Methods of treatment of such disorders and well as packaged pharmaceutical compositions are also provided. Compounds of the invention are also useful as probes for the localization of CRF receptors and as standards in assays for CRIF receptor binding. Methods of using the compounds in receptor localization studies are given.