1-[5-[(2R,3S,4S)-4-azido-3-chlorooxolan-2-yl]-2-methylfuran-3-yl]ethanone | 945214-47-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-[5-[(2R,3S,4S)-4-azido-3-chlorooxolan-2-yl]-2-methylfuran-3-yl]ethanone
• CAS: 945214-47-1
• 化学式: C₁₁H₁₂ClN₃O₃
• 分子量: 269.688
• InChiKey: KEFVSMYJFCKVGF-INTQDDNPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  53.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-[5-[(2R,3S,4S)-4-azido-3-chlorooxolan-2-yl]-2-methylfuran-3-yl]ethanone 在 三苯基膦 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Synthesis of furanosyl α-C-glycosides derived from 4-chloro-4-deoxy-α-d-galactose and their cytotoxic activities

  摘要：

  Condensation of a new unnatural sugar 1 with 1,3-dicarbonyl compounds in the presence of anhydrous zinc chloride gave the polyhydroxyalkyl-furans in excellent yields. Further modification afforded the corresponding furanosyl alpha-C-glycoside derivatives. The absolute configuration of 3-acetyl- 2-methyl-5-(2'-chloro-D-galacto-tetritol-1-yl)-furan was confirmed by single-crystal X-ray analysis. The in vitro cytotoxic activities of these furanosyl C-glycosides were also investigated. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.079
• 作为产物：
  描述：

  1-[5-[(2R,3S,4R)-3-chloro-4-hydroxyoxolan-2-yl]-2-methylfuran-3-yl]ethanone 在 吡啶 、 4-二甲氨基吡啶 、 sodium azide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 1-[5-[(2R,3S,4S)-4-azido-3-chlorooxolan-2-yl]-2-methylfuran-3-yl]ethanone
  参考文献：
  名称：

  Synthesis of furanosyl α-C-glycosides derived from 4-chloro-4-deoxy-α-d-galactose and their cytotoxic activities

  摘要：

  Condensation of a new unnatural sugar 1 with 1,3-dicarbonyl compounds in the presence of anhydrous zinc chloride gave the polyhydroxyalkyl-furans in excellent yields. Further modification afforded the corresponding furanosyl alpha-C-glycoside derivatives. The absolute configuration of 3-acetyl- 2-methyl-5-(2'-chloro-D-galacto-tetritol-1-yl)-furan was confirmed by single-crystal X-ray analysis. The in vitro cytotoxic activities of these furanosyl C-glycosides were also investigated. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.03.079