2-(3-hydroxypropylamino)-1-phenacylbenzimidazole hydrobromide | 154055-59-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3-hydroxypropylamino)-1-phenacylbenzimidazole hydrobromide
• 英文别名: 2-[2-(3-hydroxypropylamino)benzimidazol-1-yl]-1-phenylethanone;hydrobromide
• CAS: 154055-59-1
• 化学式: BrH*C₁₈H₁₉N₃O₂
• 分子量: 390.28
• InChiKey: FZCIGWIRAYULSP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.29
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  67.2
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-hydroxypropylamino)-1-phenacylbenzimidazole hydrobromide 以 C.I.酸性橙108 为溶剂， 反应 4.0h， 以82%的产率得到3-(2-phenyl-1H-imidazo[1,2-a]benzimidazol-1-yl)propan-1-ol
  参考文献：
  名称：

  Research in the field of imidazo[1,2-a]benzimidazole derivatives: XXVII. 1-acylmethyl-2-(ω-hydroxyalkylamino)-benzimidazoles and their transformation into derivatives of tricyclic systems

  摘要：

  1-Acylmethyl-2-(omega-hydroxyalkylamino)benzimidazoles were synthesized and their behavior under various conditions was investigated: at the thermolysis without solvent, at heating in DMF or in 2-aminoethanol, hydrohalic acids, and acetic anhydride, in the presence of chlorinating agents (SOCl(2), POCl(3)). Depending on the reaction conditions derivatives were obtained of 1H-imidazo[1,2-a]-benzimidazole, 9H-2,3-dihydroimidazo[1,2-a]benzimidazole, and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]-benzimidazole that were suitable synthons for the synthesis of functionally substituted derivatives of these tricyclic systems.

  DOI：

  10.1134/s1070428010020223
• 作为产物：
  描述：

  3-(1H-苯并咪唑-2-基氨基)-1-丙醇 、 2-溴苯乙酮 在 title compound 、 丙酮 、 乙醇 作用下， 以 异丙醇 为溶剂， 反应 6.0h， 生成 2-(3-hydroxypropylamino)-1-phenacylbenzimidazole hydrobromide
  参考文献：
  名称：

  Benzimidazole compounds

  摘要：

  一种从以下式子（I）中选择的抗糖尿病化合物：##STR1## 其中A、B、C、D、n、R.sub.1、R.sub.2、R.sub.3、R.sub.4、X、Y和Z的定义如说明书所述。含有该化合物的药物。

  公开号：

  US05639756A1

文献信息

• US5623073A
  申请人：——

  公开号：US5623073A

  公开（公告）日：1997-04-22
• US5639756A
  申请人：——

  公开号：US5639756A

  公开（公告）日：1997-06-17
• Research in the field of imidazo[1,2-a]benzimidazole derivatives: XXVII. 1-acylmethyl-2-(ω-hydroxyalkylamino)-benzimidazoles and their transformation into derivatives of tricyclic systems
  作者：V. A. Anisimova、I. E. Tolpygin、G. S. Borodkin

  DOI：10.1134/s1070428010020223

  日期：2010.2

  1-Acylmethyl-2-(omega-hydroxyalkylamino)benzimidazoles were synthesized and their behavior under various conditions was investigated: at the thermolysis without solvent, at heating in DMF or in 2-aminoethanol, hydrohalic acids, and acetic anhydride, in the presence of chlorinating agents (SOCl(2), POCl(3)). Depending on the reaction conditions derivatives were obtained of 1H-imidazo[1,2-a]-benzimidazole, 9H-2,3-dihydroimidazo[1,2-a]benzimidazole, and 10H-2,3,4,10-tetrahydropyrimido[1,2-a]-benzimidazole that were suitable synthons for the synthesis of functionally substituted derivatives of these tricyclic systems.
• Benzimidazole compounds
  申请人：Adir et Compagnie

  公开号：US05639756A1

  公开（公告）日：1997-06-17

  An antidiabetic compound selected from those of formula (I): ##STR1## wherein A, B, C, D, n, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y and Z are as defined in the description. Medicaments containing the same.

  一种从以下式子（I）中选择的抗糖尿病化合物：##STR1## 其中A、B、C、D、n、R.sub.1、R.sub.2、R.sub.3、R.sub.4、X、Y和Z的定义如说明书所述。含有该化合物的药物。