2-(quinolin-2-yloxy)acetic acid | 91137-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(quinolin-2-yloxy)acetic acid
• 英文别名: 2-quinolin-2-yloxyacetic acid
• CAS: 91137-38-1
• 化学式: C₁₁H₉NO₃
• 分子量: 203.197
• InChiKey: VBLMSFZRJXYEDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  59.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(quinolin-2-yloxy)acetic acid 以 四氢呋喃 为溶剂， 反应 30.0h， 生成 1-(3,4-dihydro-6,7-dimethoxyisoquinolin-2(1H)-yl)-2-(quinolin-2-yloxy)ethanone
  参考文献：
  名称：

  Activity–lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

  摘要：

  A series of alkyloxyquinoline derivatives has been developed to evaluate the relationship between P-gp potency and lipophilicity. The results show a satisfactory lipophilicity-activity correlation although a series of derivatives showing higher P-gp potency is needed in order to confirm this hypothesis. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.019
• 作为产物：
  描述：

  2-(quinolin-2-yloxy)acetonitrile 在 sodium hydroxide 作用下， 反应 6.0h， 以100%的产率得到2-(quinolin-2-yloxy)acetic acid
  参考文献：
  名称：

  Activity–lipophilicity relationship studies on P-gp ligands designed as simplified tariquidar bulky fragments

  摘要：

  A series of alkyloxyquinoline derivatives has been developed to evaluate the relationship between P-gp potency and lipophilicity. The results show a satisfactory lipophilicity-activity correlation although a series of derivatives showing higher P-gp potency is needed in order to confirm this hypothesis. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.05.019

文献信息

• [EN] ACYL PIPERAZINE DERIVATIVES AS TTX-S BLOCKERS<br/>[FR] DÉRIVÉS D'ACYLPIPÉRAZINE À TITRE DE BLOQUEURS DE TTX-S
  申请人：RAQUALIA PHARMA INC

  公开号：WO2012020567A1

  公开（公告）日：2012-02-16

  The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及酰基哌嗪衍生物，具有阻断电压门控钠通道（如TTX-S通道）活性的特性，可用于治疗或预防涉及电压门控钠通道的疾病和疾病。该发明还涉及包含这些化合物的药物组合物以及在预防或治疗涉及电压门控钠通道的疾病中使用这些化合物和组合物。
• Acyl Piperazine Derivatives as TTX-S Blockers
  申请人：Morita Mikiko

  公开号：US20130150356A1

  公开（公告）日：2013-06-13

  The present invention relates to acyl piperazine derivatives which have blocking activities of voltage gated sodium channels as the TTX-S channels, and which are useful in the treatment or prevention of disorders and diseases in which voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which voltage gated sodium channels are involved.

  本发明涉及酰基哌嗪衍生物，具有阻断电压门控钠通道（TTX-S通道）的活性，并且在治疗或预防涉及电压门控钠通道的疾病和疾病方面非常有用。本发明还涉及包含这些化合物的制药组合物以及在预防或治疗涉及电压门控钠通道的疾病中使用这些化合物和组合物的用途。
• Safened herbicidal compositions including 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof for use in rice
  申请人：Dow AgroSciences LLC

  公开号：US10172355B2

  公开（公告）日：2019-01-08

  A safened herbicidal composition for use in rice comprising a herbicidally effective amount of (a) a compound of formula (I): or an agriculturally acceptable salt or ester thereof and (b) a safener or a compatible herbicide capable of safening such as a chemical from the quinolinyloxyacetate family of chemicals, dicyclonon, daimuron, dimepiperate, fenclorim, furilazole, halosulfuron, isoxadifen-ethyl, mefenpyr-diethyl, naphthalic anhydride (NA), or agriculturally acceptable salts, esters, or mixtures thereof, for use in direct-seeded, water-seeded or transplanted rice.

  一种用于水稻的安全除草组合物，包含除草有效量的 (a) 式 (I) 化合物： 或其农业上可接受的盐或酯，以及(b)一种安全剂或一种可安全化的相容除草剂，例如喹啉基氧基乙酸酯类化学品、双环唑啉酮、唑嘧磺隆、二甲戊环唑、唑嘧磺隆、氟嘧磺隆、异氟嘧磺隆、fenclorim、furilazole、halosulfuron、isoxadifen-ethyl、mefenpyr-diethyl、naphthalic anhydride (NA)，或其农业上可接受的盐、酯或混合物，用于直播稻、水稻或移栽稻。
• Herbicide resistance genes
  申请人：Dow AgroSciences LLC

  公开号：US10174337B2

  公开（公告）日：2019-01-08

  The subject invention provides novel plants that are not only resistant to 2,4-D and other phenoxy auxin herbicides, but also to aryloxyphenoxypropionate herbicides. Heretofore, there was no expectation or suggestion that a plant with both of these advantageous properties could be produced by the introduction of a single gene. The subject invention also includes plants that produce one or more enzymes of the subject invention alone or “stacked” together with another herbicide resistance gene, preferably a glyphosate resistance gene, so as to provide broader and more robust weed control, increased treatment flexibility, and improved herbicide resistance management options. More specifically, preferred enzymes and genes for use according to the subject invention are referred to herein as AAD (aryloxyalkanoate dioxygenase) genes and proteins. No α-ketoglutarate-dependent dioxygenase enzyme has previously been reported to have the ability to degrade herbicides of different chemical classes and modes of action. This highly novel discovery is the basis of significant herbicide tolerant crop trait opportunities as well as development of selectable marker technology. The subject invention also includes related methods of controlling weeds. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the formation of, and controlling, weeds that are resistant (or naturally more tolerant) to one or more herbicides such as glyphosate.

  本发明提供的新型植物不仅能抗 2,4-D 和其他苯氧基助剂除草剂，还能抗芳基氧基苯氧基丙酸酯除草剂。在此之前，人们并不期望或认为通过引入单一基因就能培育出同时具有这两种优势特性的植物。本发明还包括单独产生一种或多种本发明酶的植物，或与另一种除草剂抗性基因（最好是草甘膦抗性基因）"叠加 "在一起的植物，从而提供更广泛、更强大的杂草控制，增加处理灵活性，改进除草剂抗性管理选择。更具体地说，根据本发明使用的优选酶和基因在此称为 AAD（芳氧基烷酸二加氧酶）基因和蛋白。以前没有报道过依赖于α-酮戊二酸的二加氧酶具有降解不同化学类别和作用方式的除草剂的能力。这一高度新颖的发现是重要的耐除草剂作物性状机会以及可选择标记技术发展的基础。本发明还包括控制杂草的相关方法。本发明可使除草剂的新组合以新的方式使用。此外，本发明还提供了防止形成和控制对一种或多种除草剂（如草甘膦）具有抗性（或天然更耐受）的杂草的新方法。
• Safening 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropyridine-2-carboxylic acid compositions in Brassica species and methods of use thereof
  申请人：Dow AgroSciences LLC

  公开号：US10219513B2

  公开（公告）日：2019-03-05

  Provided herein are safened herbicidal compositions for use in Brassica species susceptible to injury by 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropyridine-2-carboxylic acid comprising (a) a herbicidally effective amount of 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropyridine-2-carboxylic acid or an agriculturally acceptable salt or ester of thereof, and (b) a safener. The safener can be a herbicide or a herbicide safener capable of safening the Brassica species susceptible to injury by 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-5-fluoropyridine-2-carboxylic acid.

  本文提供了安全的除草组合物，用于易受 4-氨基-3-氯-6-(4-氯-2-氟-3-甲氧基苯基)-5-氟吡啶-2-羧酸伤害的芸苔属物种。(a) 除草有效量的 4-氨基-3-氯-6-(4-氯-2-氟-3-甲氧基苯基)-5-氟吡啶-2-羧酸或其农业上可接受的盐或酯、(b) 安全剂。安全剂可以是除草剂或除草安全剂，能够使易受 4-氨基-3-氯-6-(4-氯-2-氟-3-甲氧基苯基)-5-氟吡啶-2-羧酸伤害的芸苔属物种安全。