2-chloro-8-nitroquinoline-3-carbaldehyde | 335196-06-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-chloro-8-nitroquinoline-3-carbaldehyde
• 英文别名: 2-Chloro-8-nitro-3-quinolinecarboxaldehyde
• CAS: 335196-06-0
• 化学式: C₁₀H₅ClN₂O₃
• 分子量: 236.614
• InChiKey: HFPVDNRGOSLRER-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  75.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  p-(2-Benzothiazolyl)phenoxyacetylhydrazine 、 2-chloro-8-nitroquinoline-3-carbaldehyde 以 乙醇 为溶剂， 生成
  参考文献：
  名称：

  Saxena, Shivani; Kumar, Rajnish; Singh, Himanshu, Indian Journal of Heterocyclic Chemistry, 2022, vol. 32, # 3, p. 407 - 416

  摘要：

  DOI：
• 作为产物：
  描述：

  2-硝基乙酰苯胺 、 (4,6-Dichloro-[1,3,5]triazin-2-yloxymethylene)-dimethyl-ammonium; chloride 以 二氯甲烷 为溶剂， 反应 18.0h， 以82%的产率得到2-chloro-8-nitroquinoline-3-carbaldehyde
  参考文献：
  名称：

  2,4,6-Trichloro-1,3,5-triazine and N,N′-dimethylformamide as an effective Vilsmeier–Haack reagent for the synthesis of 2-chloro-3-formyl quinolines from acetanilides

  摘要：

  TCTA-DMF (2,4,6-trichloro-1,3,5-triazine/N,N'-dimethylformamide) adduct has been used as a Vilsmeier-Haack type reagent for effective synthesis of 2-chloro-3-formyl quinolines from acetanilides under conventional and ultrasonically assisted conditions. The reaction times under sonication are quite significantly shorter than conventional methods even though the yields obtained under sonication are comparable with those obtained under reflux conditions. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.07.056

文献信息

• An efficient synthesis of strained thio-bridged compounds via Pd(0) catalyzed intramolecular Csp2(aryl)-Csp3(alkyl) cross dehydrohalogenative coupling reaction
  作者：Mayur I. Morja、Janki J. Patel、Prakashsingh M. Chauhan、Kishor H. Chikhalia

  DOI：10.1016/j.tet.2020.131348

  日期：2020.8

  An operationally simple and efficient strategy employing palladium(0) catalyst to construct a wide range of thiobridged compounds through intramolecular Csp2(aryl)-Csp3(alkyl) cross-dehydrohalogenative coupling reaction has been reported. This methodology proceeds smoothly through six-membered palladacycles and serving as a keystone for the generation of C–C bond to furnish thiobridged derivative in

  已经报道了一种使用钯（0）催化剂通过分子内Csp 2（芳基）-Csp 3（烷基）交叉脱卤化氢偶合反应构建各种硫桥化合物的操作简单有效的策略。该方法通过六元的palladacycles顺利进行，并成为生成C–C键的基石，从而以良好或优异的产率提供硫桥化合物。
• Ali; Tasneem; Rajanna, Synlett, 2001, # 2, p. 251 - 253
  作者：Ali、Tasneem、Rajanna、Sai Prakash

  DOI：——

  日期：——