p-(2-Benzothiazolyl)phenoxyacetylhydrazine | 117239-46-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: p-(2-Benzothiazolyl)phenoxyacetylhydrazine
• 英文别名: 2-(4-(benzo[d]thiazol-2-yl)phenoxy)acetohydrazide；2-[4-(1,3-benzothiazole-2-yl)phenoxy]acetate hydrazide；2-[4-(1,3-Benzothiazol-2-yl)phenoxy]acetohydrazide
• CAS: 117239-46-0
• 化学式: C₁₅H₁₃N₃O₂S
• 分子量: 299.353
• InChiKey: BBAWGSTUTFHHDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  106
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  p-(2-Benzothiazolyl)phenoxyacetylhydrazine 在 溶剂黄146 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 4.17h， 生成 3--1-piperidinomethyl-2-indolinone
  参考文献：
  名称：

  Varma, Rajendra S.; Chauhan, Sudha; Prasad, C. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 438 - 442

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(1,3-苯并噻唑-2-基)苯酚 在 potassium carbonate 、 一水合肼 作用下， 以 甲醇 、 丙酮 为溶剂， 反应 26.0h， 生成 p-(2-Benzothiazolyl)phenoxyacetylhydrazine
  参考文献：
  名称：

  Varma, Rajendra S.; Chauhan, Sudha; Prasad, C. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 438 - 442

  摘要：

  DOI：

文献信息

• VARMA, RAJENDRA S.;CHAUHAN, SUDHA;PRASAD, C. R., INDIAN J. CHEM. B, 27,(1988) N 5, C. 438-442
  作者：VARMA, RAJENDRA S.、CHAUHAN, SUDHA、PRASAD, C. R.

  DOI：——

  日期：——
• Saxena, Shivani; Kumar, Rajnish; Singh, Himanshu, Indian Journal of Heterocyclic Chemistry, 2022, vol. 32, # 3, p. 407 - 416
  作者：Saxena, Shivani、Kumar, Rajnish、Singh, Himanshu、Salahuddin、Yadav, Ranjeet Kumar

  DOI：——

  日期：——
• 10.1002/cbdv.202400642
  作者：Singh, Himanshu、Kumar, Rajnish、Mazumder, Avijit、Salahuddin、Kumar Yadav, Ranjeet、Kukreti, Neelima、Abdullah, Mohd. Mustaqeem、Kumar Tyagi, Pankaj、Chaitanya

  DOI：10.1002/cbdv.202400642

  日期：——

  New 2‐(4‐benzothiazol‐2‐yl‐phenoxy)‐1‐(3,5‐diphenyl‐4,5‐dihydro‐pyrazol‐1‐yl)‐ethanones (9a‐o) have been designed and synthesized. The antiepileptic potential of the synthesized compounds has been tested by following standard animal screening models which include maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) models. The study concluded that compounds 9c, 9d, 9f, 9i, 9n, and 9o possessed good antiepileptic potential when compared with standard drugs like carbamazepine and phenytoin. The results of the rotarod performance test also established them without any neurotoxicity. The motor impairment test yielded that the synthesized compounds are also good antidepressants. In‐silico studies have been performed to determine the eligibility of synthesized compounds as orally administered molecules and interactions with the target proteins. The result of in‐silico studies reinforced results obtained by in vivo study of the synthesized compounds along with their possible mechanism of antiepileptic action i.e. via inhibiting voltage‐gated sodium channels (VGSCs) and gamma‐aminobutyric acid‐A receptor.
• Varma, Rajendra S.; Chauhan, Sudha; Prasad, C. R., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 438 - 442
  作者：Varma, Rajendra S.、Chauhan, Sudha、Prasad, C. R.

  DOI：——

  日期：——
• Saxena, Shivani; Kumar, Rajnish; Singh, Himanshu, Indian Journal of Heterocyclic Chemistry, <hi>2022</hi>, vol. 32, # 3, p. 407 - 416
  作者：Saxena, Shivani、Kumar, Rajnish、Singh, Himanshu、Salahuddin、Yadav, Ranjeet Kumar

  DOI：——

  日期：——