6,8-二甲基-2-苯基-4-喹啉醇 | 93315-54-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6,8-二甲基-2-苯基-4-喹啉醇
• 英文名称: 2-Phenyl-6,8-dimethyl-4-hydroxychinolin
• 英文别名: 4-Hydroxy-6,8-dimethyl-2-phenyl-chinolin；6,8-dimethyl-2-phenyl-quinolin-4-ol；6,8-Dimethyl-2-phenyl-chinolin-4-ol；6,8-Dimethyl-4-hydroxy-2-phenylquinoline；6,8-dimethyl-2-phenyl-1H-quinolin-4-one
• CAS: 93315-54-9
• 化学式: C₁₇H₁₅NO
• 分子量: 249.312
• InChiKey: JRPWMQRKZZMNLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  6,8-二甲基-2-苯基-4-喹啉醇 在 三氯氧磷 作用下， 生成 4-氯-6,8-二甲基-2-苯基喹啉
  参考文献：
  名称：

  Staskun, Journal of the South African Chemical Institute, 1956, vol. 9, p. 89

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 paraffin oil 作用下， 生成 6,8-二甲基-2-苯基-4-喹啉醇
  参考文献：
  名称：

  Staskun, Journal of the South African Chemical Institute, 1956, vol. 9, p. 89

  摘要：

  DOI：

文献信息

• Bangdiwala; Desai, Journal of the Indian Chemical Society, 1954, vol. 31, p. 43,46
  作者：Bangdiwala、Desai

  DOI：——

  日期：——
• Production of 3- benzoyl-2,1-benzisoxazoles,2-phenyl-4H-3,1-benzoxazin-4-ones, and novel quinolinone derivatives from 2-phenylquinolin-4(1H)-ones and sodium dichloroisocyanurate
  作者：Benjamin Staskun、Theodorus van Es

  DOI：10.1039/p19930000511

  日期：——

  A simple synthesis of certain 3-benzoyl-2,1 -benzisoxazoles 6 is accomplished via treatment of the corresponding 2-phenylquinolin-4(1H)-one 1 with sodium dichloroisocyanurate 2 in methanolic aq. alkali; the isomeric 2-phenyl-4H-3,1-benzoxazin-4-one 7 is also a product. Under different conditions the same reactants furnish two new types of quinolinone derivative, viz. 3,3-dichloro-2-phenylquinolin-4(3H)-one 4 and 2-alkoxy-3,3-dichloro-2,3-dihydro-2-phenylquinolin-4(1H)-one 5, as chief products; the former is an intermediate in the synthesis of products 6 and 7. Some of the chemical properties of the dichloro compounds 4 and 5 are described. Mechanistic pathways and proposals to explain the results and observations are presented.
• A new application of diphenylphosphorylazide (DPPA) reagent: convenient transformations of quinolin-4-one, pyridin-4-one and quinazolin-4-one derivatives into the 4-azido and 4-amino counterparts
  作者：Alexander Aizikovich、Vladimir Kuznetsov、Sofia Gorohovsky、Amalia Levy、Simha Meir、Gerardo Byk、Garry Gellerman

  DOI：10.1016/j.tetlet.2004.04.032

  日期：2004.5

  Herein, we describe a transformation of the oxo-function of a series of quinolin/pyridin/quinazolin-4-ones into 4-azido and thence into 4-amino derivatives in moderate yields by a very short and convenient new procedure using DPPA (diphenylphosphoryl azide) as reagent. A mechanism for this interesting new application of DPPA is suggested based on the identification of some of the intermediates. (C) 2004 Elsevier Ltd. All rights reserved.
• Staskun Baniamin, van Es Theodorus, J. Chem. Soc. Perkin Trans. 1, (1993) N 4, S 511- 516
  作者：Staskun Baniamin, van Es Theodorus

  DOI：——

  日期：——
• Staskun, Journal of the South African Chemical Institute, 1956, vol. 9, p. 89
  作者：Staskun

  DOI：——

  日期：——