(2S,3S,4R,5R)-methyl 3-ethyl-4,5-(isopropylidenedioxy)-3-methyltetrahydrofuran-2-methanol | 115142-31-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2S,3S,4R,5R)-methyl 3-ethyl-4,5-(isopropylidenedioxy)-3-methyltetrahydrofuran-2-methanol
• 英文别名: [(3aR,5S,6R,6aR)-6-ethyl-2,2,6-trimethyl-5,6a-dihydro-3aH-furo[2,3-d][1,3]dioxol-5-yl]methanol
• CAS: 115142-31-9
• 化学式: C₁₁H₂₀O₄
• 分子量: 216.277
• InChiKey: HCSZNNRWSRPKOR-PKIKSRDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (2R,3R,4R,5S)-4-ethyl-2,3-(isopropylidenedioxy)-5-<(1R)-1,2-(isopropylidenedioxy)ethyl>-4-methyltetrahydrofuran 在 sodium tetrahydroborate 、 sodium periodate 、 溶剂黄146 作用下， 以 甲醇 为溶剂， 反应 62.67h， 生成 (2S,3S,4R,5R)-methyl 3-ethyl-4,5-(isopropylidenedioxy)-3-methyltetrahydrofuran-2-methanol
  参考文献：
  名称：

  Synthesis of (3S,4S)-dihydro-4-ethyl-3-hydroxy-4-methyl-2(3H)-furanone, a pantolactone homolog isolated from Marshallia tenuifolia

  摘要：

  DOI：

  10.1021/jo00251a043

文献信息

• TADANO, KIN-ICHI;KANAZAWA, SATOSHI;OGAWA, SEIICHIRO, J. ORG. CHEM., 53,(1988) N 16, C. 3868-3870
  作者：TADANO, KIN-ICHI、KANAZAWA, SATOSHI、OGAWA, SEIICHIRO

  DOI：——

  日期：——
• 3'-SUBSTITUTED METHYL OR ALKYNYL NUCLEOSIDES NUCLEOTIDES FOR THE TREATMENT OF HCV
  申请人：IDENIX PHARMACEUTICALS LLC

  公开号：US20170044205A1

  公开（公告）日：2017-02-16

  Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 3′-substituted methyl or alkynyl nucleosides of Formula I: (I); or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein Base, PD, R A , R B1 , R B2 , R C and Z are as defined herein.