3',4'-di-O-methyl-(-)-epicatechin | 97914-17-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3',4'-di-O-methyl-(-)-epicatechin
• 英文别名: Epicatechin 3',4'-dimethyl ether；(2R,3R)-2-(3,4-dimethoxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol
• CAS: 97914-17-5
• 化学式: C₁₇H₁₈O₆
• 分子量: 318.326
• InChiKey: INGGXWWOTDZRPX-CXAGYDPISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  88.4
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  重氮甲烷 、 3',4'-di-O-methyl-(-)-epicatechin 以 乙醚 、 乙醇 为溶剂， 以5 mg的产率得到5,7,3',4'-tetra-O-methylepicatechin
  参考文献：
  名称：

  Morimoto, Satoshi; Nonaka, Gen-Ichiro; Nishioka, Itsuo, Chemical and pharmaceutical bulletin, 1985, vol. 33, # 6, p. 2281 - 2286

  摘要：

  DOI：
• 作为产物：
  描述：

  Carbonic acid benzyl ester (2R,3R)-5-benzyloxycarbonyloxy-2-(3,4-dimethoxy-phenyl)-3-hydroxy-chroman-7-yl ester 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以100%的产率得到3',4'-di-O-methyl-(-)-epicatechin
  参考文献：
  名称：

  Selective O-methylation of polyhydroxyflavan-3-ols via benzyl carbonates

  摘要：

  DOI：

  10.1016/0040-4039(90)80149-g

文献信息

• Chemosensory receptor ligand-based therapies
  申请人：Anji Pharma (US) LLC

  公开号：US10610500B2

  公开（公告）日：2020-04-07

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.

  本文提供了通过施用包含化感受体配体（如苦味受体配体）的组合物来治疗与化感受体相关的病症（包括糖尿病、肥胖症和其他代谢性疾病、失调或病症）的方法。本文还提供了化学感觉受体配体组合物，包括苦味受体配体组合物，及其用于本发明方法的制备方法。本文还提供了包含二甲双胍及其盐类的组合物和使用方法。
• VAN, DYK MARTHA S.;STEYNBERG, JAN P.;STEYNBERG, PETRUS J.;FERREIRA, DANEE+, TETRAHEDRON LETT., 31,(1990) N8, C. 2643-2646
  作者：VAN, DYK MARTHA S.、STEYNBERG, JAN P.、STEYNBERG, PETRUS J.、FERREIRA, DANEE+

  DOI：——

  日期：——
• CHEMOSENSORY RECEPTOR LIGAND-BASED THERAPIES
  申请人：Anji Pharma (US) LLC

  公开号：EP2661266B1

  公开（公告）日：2020-09-16
• Synthesis of oligo/poly(catechins) and methods of use
  申请人：Bruno Ferdinando F.

  公开号：US20090170928A1

  公开（公告）日：2009-07-02

  A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.
• Chemosensory Receptor Ligand-Based Therapies
  申请人：BARON Alain D.

  公开号：US20120177730A1

  公开（公告）日：2012-07-12

  Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administrating a composition comprising a chemosensory receptor ligand, such as a bitter receptor ligand. Also provided herein are chemosensory receptor ligand compositions, including bitter receptor ligand compositions, and methods for the preparation thereof for use in the methods of the present invention. Also provided herein are compositions comprising metformin and salts thereof and methods of use.