4-(4-Methoxy-benzoyl)-1,5-dimethyl-1,3-dihydro-imidazol-2-one | 85473-96-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(4-Methoxy-benzoyl)-1,5-dimethyl-1,3-dihydro-imidazol-2-one
• 英文别名: 5-(4-methoxybenzoyl)-3,4-dimethyl-1H-imidazol-2-one
• CAS: 85473-96-7
• 化学式: C₁₃H₁₄N₂O₃
• 分子量: 246.266
• InChiKey: FAMAFNCHKSPHBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-Methoxy-benzoyl)-1,5-dimethyl-1,3-dihydro-imidazol-2-one 、 乙酸酐 生成 1,3-diacetyl-1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-2-one
  参考文献：
  名称：

  GRISAR, J. M.;SCHNEITTLER, R. A. =, DAGE, R. C.

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-1,3-imidazol-2-one 、 碘甲烷 生成 4-(4-Methoxy-benzoyl)-1,5-dimethyl-1,3-dihydro-imidazol-2-one
  参考文献：
  名称：

  GRISAR, J. M.;SCHNEITTLER, R. A. =, DAGE, R. C.

  摘要：

  DOI：

文献信息

• 4-Aroyl-1,3-dihydro-2H-imidazol-2-ones, a new class of cardiotonic agents
  作者：Richard A. Schnettler、Richard C. Dage、J. Martin Grisar

  DOI：10.1021/jm00354a017

  日期：1982.12

  A series of 4-aroyl-1,3-dihydro-2H-imidazol-2-ones was synthesized and evaluated for pharmacological activity in the anesthetized dog. Most members of this series produced dose-related increases in cardiac contractile force as well as relatively minor increases in heart rate and decreases in systemic arterial blood pressure that were not blocked by propranolol. In general, 4-methoxy or 4-methylthiobenzoyl substitution afforded compounds of greatest inotropic potency. 1,3-Dihydro-4-(4-methoxybenzoyl)-5-methyl-2H-imidazol-one (6) was shown to produce a dose-related positive inotropic effect and reverse the depressant effect of pentobarbital on cardiac pump function in the dog heart-lung preparation. The cardiotonic activity of this series may have important utility in the treatment of congestive heart failure. 1,3-Dihydro-4-[4-(methylthio)benzoyl]-5-methyl-2H-imidazol-2-one (17) was chosen for human studies and is currently undergoing clinical trials.
• GRISAR, J. M.;SCHNEITTLER, R. A. =, DAGE, R. C.
  作者：GRISAR, J. M.、SCHNEITTLER, R. A. =, DAGE, R. C.

  DOI：——

  日期：——