4',5'-bis(hydroxymethyl)fluorescein dibenzoate | 1344032-74-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 4',5'-bis(hydroxymethyl)fluorescein dibenzoate
• 英文别名: [6'-Benzoyloxy-4',5'-bis(hydroxymethyl)-3-oxospiro[2-benzofuran-1,9'-xanthene]-3'-yl] benzoate
• CAS: 1344032-74-1
• 化学式: C₃₆H₂₄O₉
• 分子量: 600.581
• InChiKey: GYJTWDSHMFDJIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  45
• 可旋转键数：
  8
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  129
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  4',5'-bis(hydroxymethyl)fluorescein dibenzoate 、 beta-D-半乳糖五乙酸酯 在 三氟化硼乙醚 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以66%的产率得到
  参考文献：
  名称：

  Studies on the synthesis and the antimicrobial and antioxidant activities of a novel class of fluorescein-based glycosides

  摘要：

  Facile glycosylation of a fluorescein diol derivative with per-O-acetylibenzoyl sugar derivatives using BF3 center dot Et2O catalyst resulted in the formation of the expected glycosides in 54-66% yield. The biological screening of the glycosides against different microbes shows good inhibitory activity. The antioxidant activity of the fluorescein-based glycosides shows remarkable inhibition (IC50 similar to 80%). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.08.005
• 作为产物：
  描述：

  4',5'-bis(bromomethyl)fluoresceine dibenzoate 在 水 、 碳酸氢钠 作用下， 以 乙腈 为溶剂， 反应 2.0h， 以68%的产率得到4',5'-bis(hydroxymethyl)fluorescein dibenzoate
  参考文献：
  名称：

  Studies on the synthesis and the antimicrobial and antioxidant activities of a novel class of fluorescein-based glycosides

  摘要：

  Facile glycosylation of a fluorescein diol derivative with per-O-acetylibenzoyl sugar derivatives using BF3 center dot Et2O catalyst resulted in the formation of the expected glycosides in 54-66% yield. The biological screening of the glycosides against different microbes shows good inhibitory activity. The antioxidant activity of the fluorescein-based glycosides shows remarkable inhibition (IC50 similar to 80%). (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.carres.2011.08.005

文献信息

• US7160732B2
  申请人：——

  公开号：US7160732B2

  公开（公告）日：2007-01-09
• Studies on the synthesis and the antimicrobial and antioxidant activities of a novel class of fluorescein-based glycosides
  作者：Mani Rajasekar、Raman Jegadeesh、Nanjian Raaman、Thangamuthu Mohan Das

  DOI：10.1016/j.carres.2011.08.005

  日期：2011.11

  Facile glycosylation of a fluorescein diol derivative with per-O-acetylibenzoyl sugar derivatives using BF3 center dot Et2O catalyst resulted in the formation of the expected glycosides in 54-66% yield. The biological screening of the glycosides against different microbes shows good inhibitory activity. The antioxidant activity of the fluorescein-based glycosides shows remarkable inhibition (IC50 similar to 80%). (C) 2011 Elsevier Ltd. All rights reserved.