1-Ethyl-5,6,8-trifluoro-1,4-dihydro-7-(4-morpholinyl)-4-oxo-3-quinolinecarboxylic acid | 111760-12-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Ethyl-5,6,8-trifluoro-1,4-dihydro-7-(4-morpholinyl)-4-oxo-3-quinolinecarboxylic acid
• 英文别名: 1-ethyl-5,6,8-trifluoro-7-morpholin-4-yl-4-oxoquinoline-3-carboxylic acid
• CAS: 111760-12-4
• 化学式: C₁₆H₁₅F₃N₂O₄
• 分子量: 356.301
• InChiKey: NFCOQWNOYFPOAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  吗啉 、 1-ethyl-5,6,7,8-tetrafluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 以 N-甲基吡咯烷酮 为溶剂， 生成 1-Ethyl-5,6,8-trifluoro-1,4-dihydro-7-(4-morpholinyl)-4-oxo-3-quinolinecarboxylic acid
  参考文献：
  名称：

  7-(substituted)piperaziny

  摘要：

  7-(取代)哌嗪基-1-乙基-6-氟-4-氧代-3-喹啉羧酸，其药理上可接受的盐，含有它们的组合物，生产它们的过程和中间体，以及使用它们治疗温血动物细菌感染的方法。

  公开号：

  US04940710A1

文献信息

• 7-(substituted)piperaziny
  申请人：American Cyanamid Company

  公开号：US04940710A1

  公开（公告）日：1990-07-10

  7-(substituted)piperazinyl-1-ethyl-6-fluoro-4-oxo-3-quinolinecarboxylic acids, the pharmacologically acceptable salts thereof, compositions containing them, processes and intermediates for producing them, and methods of using them to treat bacterial infections in warm-blooded animals.

  7-(取代)哌嗪基-1-乙基-6-氟-4-氧代-3-喹啉羧酸，其药理上可接受的盐，含有它们的组合物，生产它们的过程和中间体，以及使用它们治疗温血动物细菌感染的方法。
• Synthesis of novel 5-fluoro analogs of norfloxacin and ciprofloxacin
  作者：Daniel B. Moran、Carl B. Ziegler、Theresa S. Dunne、Nydia A. Kuck、Yang I Lin

  DOI：10.1021/jm00126a028

  日期：1989.6

  A series of polyfluoro-3-quinolonecarboxylic acids have been synthesized and their in vitro antibacterial activity evaluated. The desired 7-(substituted amino) derivatives were prepared from the 5,6,7,8-tetrafluoroquinolone acids. Conversely, amine displacement occurred primarily at the 5-position when the ester was used. Structure-activity studies indicated that the antibacterial activity was greatest when the N-1 substituent was cyclopropyl and the 7-substituent was 4-methyl-1-piperazinyl. All 5-(substituted amino) derivatives showed poor in vitro activity.
• US4940710A
  申请人：——

  公开号：US4940710A

  公开（公告）日：1990-07-10
• Synthesis of norfloxacin analogues catalyzed by Lewis and Brönsted acids: An alternative pathway
  作者：Socorro Leyva、Hiram Hernández

  DOI：10.1016/j.jfluchem.2010.07.002

  日期：2010.10

  An alternative synthetic pathway to prepare norfloxacin analogues is presented. Three Lewis acids (CeCl3 center dot 7H(2)O, AlCl3 center dot 6H(2)O, ZnCl2) and one Bronsted acid (TsOH) were tested as catalysts in the preparation of 3,4-difluoroacrylate. Cyclization of this acrylate at 55 degrees C was achieved with the use of Eaton's reagent (P2O5/MeSO3H) a known Bronsted acid. The fluoroquinolone-boron complex presented high yields on C-7 nucleophilic substitution of the fluorine atom by different heterocyclic amines with low, medium and strong nucleophilic character. (C) 2010 Elsevier B.V. All rights reserved.