2-bromo-1-(3-hydroxyphenyl)propan-1-one | 62932-91-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-bromo-1-(3-hydroxyphenyl)propan-1-one
• CAS: 62932-91-6
• 化学式: C₉H₉BrO₂
• 分子量: 229.073
• InChiKey: CHMVGIVXRHTOAK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-bromo-1-(3-hydroxyphenyl)propan-1-one 在 甲酸 、 碳酸氢钠 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 17.0h， 生成 tert-butyl 2-(3-hydroxyphenyl)-3-methylmorpholine-4-carboxylate
  参考文献：
  名称：

  2-PHENYLMORPHOLINE AND 2-PHENYL(THIO)MORPHOLINE COMPOUNDS AND USES THEREOF

  摘要：

  Provided herein is a compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X, Y, R1, R2, R3, R4, m, n, o) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Structural Formula I, or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing,e.g., to treat a neurological or psychiatric disease or disorder, or a metabolic disease, disorder or condition.

  公开号：

  WO2024118488A1
• 作为产物：
  描述：

  3'-羟基苯丙酮 在 溴 作用下， 以 二氯甲烷 为溶剂， 生成 2-bromo-1-(3-hydroxyphenyl)propan-1-one
  参考文献：
  名称：

  2-PHENYLMORPHOLINE AND 2-PHENYL(THIO)MORPHOLINE COMPOUNDS AND USES THEREOF

  摘要：

  Provided herein is a compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X, Y, R1, R2, R3, R4, m, n, o) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Structural Formula I, or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing,e.g., to treat a neurological or psychiatric disease or disorder, or a metabolic disease, disorder or condition.

  公开号：

  WO2024118488A1

文献信息

• Imidazo[2,1-b]benzothiazoles. 2. New immunosuppressive agents
  作者：Toshiyasu Mase、Hideki Arima、Kenichi Tomioka、Toshimitsu Yamada、Kiyoshi Murase

  DOI：10.1021/jm00153a014

  日期：1986.3

  A series of 2-phenylimidazo[2,1-b]benzothiazole derivatives was prepared and tested for immunological activities. Some of the compounds showed significant suppressive activity of delayed type hypersensitivity (DTH) without inhibition of humoral immunity in mice by oral administration. The most active compound was 2-(m-hydroxyphenyl)imidazo[2,1-b]benzothiazole (20).
• MASE, TOSHIYASU;ARIMA, HIDEKI;TOMIOKA, KENICHI;YAMADA, TOSHIMITSU;MURASE,+, J. MED. CHEM., 1986, 29, N 3, 386-394
  作者：MASE, TOSHIYASU、ARIMA, HIDEKI、TOMIOKA, KENICHI、YAMADA, TOSHIMITSU、MURASE,+

  DOI：——

  日期：——
• 2-PHENYLMORPHOLINE AND 2-PHENYL(THIO)MORPHOLINE COMPOUNDS AND USES THEREOF
  申请人：[en]SUMITOMO PHARMA AMERICA, INC.

  公开号：WO2024118488A1

  公开（公告）日：2024-06-06

  Provided herein is a compound of Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein values for the variables (e.g., X, Y, R1, R2, R3, R4, m, n, o) are as disclosed herein. Also provided herein are pharmaceutical compositions comprising a compound of Structural Formula I, or a pharmaceutically acceptable salt thereof, and methods of using the compounds, pharmaceutically acceptable salts thereof and pharmaceutical compositions of the foregoing,e.g., to treat a neurological or psychiatric disease or disorder, or a metabolic disease, disorder or condition.