5-Chlormethyl-1-methyl-3-phenyl-1,2,4-triazol | 26254-15-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-Chlormethyl-1-methyl-3-phenyl-1,2,4-triazol
• 英文别名: 5-chloromethyl-1-methyl-3-phenyl-1H-[1,2,4]triazole；5-(chloromethyl)-1-methyl-3-phenyl-1H-1,2,4-triazole；5-(chloromethyl)-1-methyl-3-phenyl-1,2,4-triazole
• CAS: 26254-15-9
• 化学式: C₁₀H₁₀ClN₃
• 分子量: 207.662
• InChiKey: ULWGBSWRGPGVFF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-Chlormethyl-1-methyl-3-phenyl-1,2,4-triazol 在 sodium perchlorate 、 sodium carbonate 作用下， 以 吡啶 、 水 为溶剂， 反应 14.0h， 生成 4-Dimethylamino-N-<(1-methyl-3-phenyl-1,2,4-triazol-5-yl)methylen>anilin
  参考文献：
  名称：

  Moderhack, Dietrich, Liebigs Annalen der Chemie, 1984, # 1, p. 48 - 65

  摘要：

  DOI：
• 作为产物：
  描述：

  甲基肼 、 alkaline earth salt of/the/ methylsulfuric acid 以 四氢呋喃 为溶剂， 反应 4.0h， 以75%的产率得到5-Chlormethyl-1-methyl-3-phenyl-1,2,4-triazol
  参考文献：
  名称：

  Synthese de 5-Aryl-3-[(1-dialcoxyphosphonyl)methyl]-1,2,4-triazoles a Partir d'Imidates N-Chloroacyles

  摘要：

  A variety of 5-aryl-3-[(1-dialcoxyphosphonyl)methyl]-1,2,4-triazoles 3 has been synthesized efficiently by treatment of trialkylphosphites with 5-aryl-3-chloromethyl-1,2,4-triazoles 2. Compound 2 has been prepared by action of N-chloroacylimidates 1 with hydrazines. The structure of triazoles 2 and 3 have been unequivocally confirmed by means of IR, H-1, C-13, P-31 NMR spectroscopy and mass spectra.

  DOI：

  10.1080/10426500214557

文献信息

• Antihyperglycemic activity of new 1,2,4-oxadiazolidine-3,5-diones
  作者：M Malamas

  DOI：10.1016/s0223-5234(00)01191-0

  日期：2001.1

  A series of 1,2,4-oxadiazolidine-3,5-diones was synthesized and evaluated as oral antihyperglycemic agents in the obese insulin resistant db/db and ob/ob mouse - the two models for Type 2 diabetes mellitus. The majority of the prepared methoxy- and ethoxy-linked oxazole 1,2,4-oxadiazolidine-3,5-diones normalized plasma glucose levels at the 100 mg kg(-1) oral dose in the db/db diabetic mouse model, and several amongst them reduced the glucose levels at the 20 mg kg(-1) oral dose. The most potent compounds in the db/db mouse model were also active in the ob/ob mouse model normalizing the plasma glucose levels at the 20 mg kg(-1) oral dose. The trifluoromethoxy analog 32 was the most active compound of the series, reducing significantly the plasma glucose levels at the 5 mg kg(-1) oral dose. Oxadiazole-tailed 1,2,4-oxadiazolidine-3,5-diones were also active in both the db/db and ob/ob diabetic mouse models normalizing plasma glucose levels at the 100 mg kg(-1) oral dose. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
• MODERHACK, D., LIEBIGS ANN. CHEM., 1984, N 1, 48-65
  作者：MODERHACK, D.

  DOI：——

  日期：——
• Synthese de 5-Aryl-3-[(1-dialcoxyphosphonyl)methyl]-1,2,4-triazoles a Partir d'Imidates N-Chloroacyles
  作者：Abdallah Harizi、Noureddine Saïd、Zine Mighri、Hédi Zantour

  DOI：10.1080/10426500214557

  日期：2002.11.1

  A variety of 5-aryl-3-[(1-dialcoxyphosphonyl)methyl]-1,2,4-triazoles 3 has been synthesized efficiently by treatment of trialkylphosphites with 5-aryl-3-chloromethyl-1,2,4-triazoles 2. Compound 2 has been prepared by action of N-chloroacylimidates 1 with hydrazines. The structure of triazoles 2 and 3 have been unequivocally confirmed by means of IR, H-1, C-13, P-31 NMR spectroscopy and mass spectra.
• Moderhack, Dietrich, Liebigs Annalen der Chemie, 1984, # 1, p. 48 - 65
  作者：Moderhack, Dietrich

  DOI：——

  日期：——