7-amino-5-<1-hydroxy-2-(isopropylamino)butyl>carbostyril | 77405-40-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-amino-5-<1-hydroxy-2-(isopropylamino)butyl>carbostyril
• 英文别名: 7-amino-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one
• CAS: 77405-40-4
• 化学式: C₁₆H₂₃N₃O₂
• 分子量: 289.378
• InChiKey: XVHAPCWGQRPNEV-UHFFFAOYSA-N

物化性质

• 沸点：
  556.3±50.0 °C(Predicted)
• 密度：
  1.168±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-amino-5-<1-hydroxy-2-(isopropylamino)butyl>carbostyril 在 硫酸 、 水 、 sodium nitrite 作用下， 生成 erythro-5-<1-hydroxy-2-(isopropylamino)butyl>-7-hydroxycarbostyril
  参考文献：
  名称：

  Erythro-5-[1-hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol

  摘要：

  erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril (4), which is a terbutaline-type derivative of the bronchodilator procaterol, was synthesized by transfer of the 8-hydroxyl group of procaterol to the 7 position. Compound 4 showed less potent beta-adrenoceptor stimulant activities than procaterol or terbutaline in an in vitro test using guinea pig tracheal muscle and right atrium. In an in vivo assay on anesthetized dogs, compound 4 showed 42 times less bronchodilator activity and 87 times less effect on the heart rate than l-isoproterenol.

  DOI：

  10.1021/jm00137a030
• 作为产物：
  描述：

  7-amino-5-<1-hydroxy-2-(isopropylamino)butyl>-8-(mesyloxy)carbostyril 在 钯 氢氧化钾 、 氢气 作用下， 反应 20.0h， 以99%的产率得到7-amino-5-<1-hydroxy-2-(isopropylamino)butyl>carbostyril
  参考文献：
  名称：

  Erythro-5-[1-hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol

  摘要：

  erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril (4), which is a terbutaline-type derivative of the bronchodilator procaterol, was synthesized by transfer of the 8-hydroxyl group of procaterol to the 7 position. Compound 4 showed less potent beta-adrenoceptor stimulant activities than procaterol or terbutaline in an in vitro test using guinea pig tracheal muscle and right atrium. In an in vivo assay on anesthetized dogs, compound 4 showed 42 times less bronchodilator activity and 87 times less effect on the heart rate than l-isoproterenol.

  DOI：

  10.1021/jm00137a030

文献信息

• TAMURA, YUKIMITSU;JOSIDZAKI, SIRO;NAKAGAVA, KADZUYUKI
  作者：TAMURA, YUKIMITSU、JOSIDZAKI, SIRO、NAKAGAVA, KADZUYUKI

  DOI：——

  日期：——