3-[2-(Cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-N-isopropylpyrazolo[1,5-alpha]pyridin-5-amine | 473712-01-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3-[2-(Cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-N-isopropylpyrazolo[1,5-alpha]pyridin-5-amine
• 英文别名: 3-[2-(cyclopentylamino)pyrimidin-4-yl]-2-(4-fluorophenyl)-N-propan-2-ylpyrazolo[1,5-a]pyridin-5-amine
• CAS: 473712-01-5
• 化学式: C₂₅H₂₇FN₆
• 分子量: 430.528
• InChiKey: FDXDGPUMMWYVHH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  67.1
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-[5-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine 、 异丙胺 在 palladium diacetate caesium carbonate 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 作用下， 反应 24.0h， 生成 3-[2-(Cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-N-isopropylpyrazolo[1,5-alpha]pyridin-5-amine
  参考文献：
  名称：

  Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity

  摘要：

  Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo [1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.11.120
• 作为试剂：
  描述：

  4-[5-chloro-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-cyclopentyl-2-pyrimidinamine 、 异丙胺 、 R-(+)-1,1'-联萘-2,2'-双二苯膦 、 Dicaesio carbonate 在 醋酸钯 hexanes-ethyl acetate 、 3-[2-(Cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-N-isopropylpyrazolo[1,5-alpha]pyridin-5-amine 作用下， 生成 3-[2-(Cyclopentylamino)-4-pyrimidinyl]-2-(4-fluorophenyl)-N-isopropylpyrazolo[1,5-alpha]pyridin-5-amine
  参考文献：
  名称：

  Antiviral pyrazolopyridine compounds

  摘要：

  本发明提供了公式（I）的化合物，包含它们的药物组合物，制备它们的过程以及它们作为药物制剂的用途。这些化合物在预防和治疗疱疹病毒感染方面非常有用。

  公开号：

  US20040167335A1

文献信息

• Antiviral Pyrazolopyridine Compounds
  申请人：Cheung Mui

  公开号：US20060235043A1

  公开（公告）日：2006-10-19

  The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

  本发明提供了式(I)的化合物：含有该化合物的药物组合物，制备该化合物的方法以及它们作为药物代理的用途。
• ANTIVIRAL PYRAZOLOPYRIDINE COMPOUNDS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1377575B1

  公开（公告）日：2006-07-05
• Pyrazolopyridines with potent activity against herpesviruses: Effects of C5 substituents on antiviral activity
  作者：Kristjan S. Gudmundsson、Brian A. Johns、Scott H. Allen

  DOI：10.1016/j.bmcl.2007.11.120

  日期：2008.2

  Synthesis of a series of 5-substituted as well as 5,7-disubstituted 3-[2-(cyclopentylamino)-4-pyrimidinyl]-2-phenylpyrazolo [1,5-a]pyridin-7-amines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the substitution pattern are outlined and resulting changes in antiviral activity are highlighted. Several compounds with in vitro antiviral activity similar to or better than acyclovir are described. (C) 2007 Elsevier Ltd. All rights reserved.
• Antiviral pyrazolopyridine compounds
  申请人：——

  公开号：US20040167335A1

  公开（公告）日：2004-08-26

  The present invention provides compounds of formula (I), pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents. The compounds are useful in the prophylaxis treatment of herpes viral infections. 1

  本发明提供了公式（I）的化合物，包含它们的药物组合物，制备它们的过程以及它们作为药物制剂的用途。这些化合物在预防和治疗疱疹病毒感染方面非常有用。