6-acetoxyazulene | 19390-91-1

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 6-acetoxyazulene
• 英文别名: 6-Acetoxyazulen；Azulen-6-yl acetate
• CAS: 19390-91-1
• 化学式: C₁₂H₁₀O₂
• 分子量: 186.21
• InChiKey: XXIASJVGYJGMFS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-acetoxyazulene 、 N,N-二甲基甲酰胺 、 三氯氧磷 以34%的产率得到
  参考文献：
  名称：

  MORITA, TADAYOSHI;ISE, FUMIAKI;TAKASE, KAHEI, CHEM. LETT., 1981, N 12, 1661-1662

  摘要：

  DOI：

文献信息

• SYNTHESIS OF 1-(DIMETHYLAMINOMETHYLENE)-6(1<i>H</i>)-AZULENONE, A 1,6-AZULENEQUINONE 1-METHIDE DERIVATIVE
  作者：Tadayoshi Morita、Fumiaki Ise、Kahei Takase

  DOI：10.1246/cl.1981.1661

  日期：1981.12.5

  Reaction of 6-hydroxyazulene with DMF-POCl3 followed by treatment with aq HN(CH3)2 gave 1-(dimethylaminomethylene)-6(1H)-azulenone (2) in 100% yield. Treatment of 2 with Ac2O generated 6-acetoxy-1-formylazulene (3) which was hydrolyzed with aq HN(CH3)2 at room temp to give 1-formyl-6-hydroxyazulene (4). Upon heating of 3 with aq HN(CH3)2, 2 was obtained. Alkaline hydrolysis of 2 afforded 4.

  6-羟基-1-氮杂萘与DMF-POCl3反应，然后与aq HN(CH3)2反应，得到1-(二甲基氨基亚甲基)-6(1H)-氮杂萘酮(2)，收率100%。2与Ac2O反应生成6-乙酰氧基-1-甲酰基氮杂萘(3)，在室温下与aq HN( )2水解得到1-甲酰基-6-羟基氮杂萘(4)。加热3与aq HN( )2反应，得到2。2的碱性水解得到4。
• Perfume compositions
  申请人：Behan John Martin

  公开号：US20080255024A1

  公开（公告）日：2008-10-16

  A perfume composition comprises: e) at least about 25% by weight in total of at least five selected relaxing fragrance materials (R); f) optionally up to about 45% by weight in total of non-relaxing fragrance materials (NR), provided that the ratio by weight of R to NR is at least 0.75; g) optionally up to about 75% by weight in total of neutral fragrance materials (N); h) optionally up to about 25% by weight of other fragrance materials (M) provided that the weight ratio R to (M+NR) at least 0.75; and wherein all percentages are based on total weight of the fragrance materials consisting the perfume composition.