tetraethylene glycol propyl ether | 23307-36-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: tetraethylene glycol propyl ether
• 英文别名: Tetraaethylenglykol-mono-propylaether；2-{2-[2-(2-propoxy-ethoxy)-ethoxy]-ethoxy}-ethanol；3,6,9,12-Tetraoxapentadecan-1-ol；2-[2-[2-(2-propoxyethoxy)ethoxy]ethoxy]ethanol
• CAS: 23307-36-0
• 化学式: C₁₁H₂₄O₅
• 分子量: 236.309
• InChiKey: SXNRWWNGEQMQCB-UHFFFAOYSA-N

物化性质

• 沸点：
  135 °C(Press: 1 Torr)
• 密度：
  1.0200 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  16
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  57.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  正己醛 、 tetraethylene glycol propyl ether 在 对甲苯磺酸 作用下， 生成 1,1-bis-(2-{2-[2-(2-propoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-hexane
  参考文献：
  名称：

  Sokolowski,A.; Burczyk,B., Polish Journal of Chemistry, 1979, vol. 53, p. 905 - 912

  摘要：

  DOI：

文献信息

• TAU-PROTEIN TARGETING PROTACS AND ASSOCIATED METHODS OF USE
  申请人：Arvinas, Inc.

  公开号：US20180125821A1

  公开（公告）日：2018-05-10

  The present disclosure relates to bifunctional compounds, which find utility as modulators of tau protein. In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a VHL or cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds tau protein, such that tau protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of tau. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of tau protein. Diseases or disorders that result from aggregation or accumulation of tau protein are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，其作为tau蛋白的调节剂具有实用性。具体而言，本公开涉及含有一端结合到E3泛素连接酶的VHL或cereblon配体，另一端结合到tau蛋白的双功能化合物，使得tau蛋白与泛素连接酶靠近，以实现tau蛋白的降解（和抑制）。本公开展示了与tau蛋白降解/抑制相关的广泛药理活性。本公开的化合物和组合物用于治疗或预防由tau蛋白聚集或积累导致的疾病或紊乱。
• LOW VISCOSITY LOW VOLATILITY LUBRICATING OIL BASE STOCKS AND METHODS OF USE THEREOF
  申请人：ExxonMobil Research and Engineering Company

  公开号：US20170183595A1

  公开（公告）日：2017-06-29

  A lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. The lubricating oil base stock has a high temperature high shear (HTHS) viscosity of less than about 1.7 cP as determined by ASTM D4683, and a Noack volatility from about 15 to about 90 percent as determined by ASTM D5800. A lubricating oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein. A method for improving one or more of thermal and oxidative stability, solubility and dispersancy of polar additives, deposit control and traction control in a lubricating oil by using as the lubricating oil a formulated oil containing the lubricating oil base stock including one or more monoesters represented by the formula (I), (II), (III) and (IV) as defined herein.

  一种润滑油基础油，包括根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯。该润滑油基础油的高温高剪切（HTHS）粘度小于约1.7厘泊，由ASTM D4683确定，挥发性从约15%到约90%，由ASTM D5800确定。一种含有根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯的润滑油基础油的润滑油。一种通过使用包含根据本文所定义的公式(I)、(II)、(III)和(IV)表示的一个或多个单酯的润滑油基础油的配制油来改善润滑油中的热稳定性、氧化稳定性、溶解性和分散性、沉积控制和牵引控制的方法。
• ANTICANCER DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF
  申请人：SANOFI

  公开号：US20130137659A1

  公开（公告）日：2013-05-30

  Provided herein are compounds of formula (I):

  本文提供的是式(I)的化合物：
• Oil agent and lubricant agent, moisturizer and external preparation composition containing the same
  申请人：Takeda Kyoichi

  公开号：US20080200544A1

  公开（公告）日：2008-08-21

  The present invention provides an oil agent having water solubility and oil solubility, as well as suppressed stickiness when applied to skin to exhibit excellent feeling of use, and also provides a lubricating agent, a moisturizing agent and an external preparation containing said oil agent. The oil agent of the present invention comprises a dibasic acid ester compound of general formula I: wherein R 1 is an alkylene group having a carbon number of 2-4, which may be mono- or poly substituted, R 2 and R 3 are, independently of each other, an alkyl group having a carbon number of 1-4, which may be mono- or poly substituted, n and m are, independently of each other, an integer of 0-4 with m+n≧1 (provided that the cases wherein both of R 2 and R 3 are an ethyl group and both of n and m are 1 are excluded).

  本发明提供了一种具有水溶性和油溶性的油剂，当涂抹在皮肤上时，具有抑制粘性，展现出优秀的使用感受，同时提供了一种润滑剂、保湿剂和含有该油剂的外用制剂。本发明的油剂包括一种一般式I的二元酸酯化合物：其中R1是碳数为2-4的烷基基团，可以是单取代或多取代，R2和R3分别是碳数为1-4的烷基基团，可以是单取代或多取代，n和m分别是0-4的整数，满足m+n≥1（排除R2和R3均为乙基基团，n和m均为1的情况）。
• Glycol Ether Neo-Esters, Lubricating Oil Compositions Containing Same And Processes For Making Same
  申请人：ExxonMobil Research and Engineering Company

  公开号：US20200399552A1

  公开（公告）日：2020-12-24

  Compositions include ether ester compounds derived from neo-acids, lubricating oil base stocks containing such ester compounds, and lubricating oil compositions containing such ester compounds. Methods can include making and formulating compositions containing ether ester compounds derived from neo-acids.

  这段话的中文翻译如下： 该组合物包括从新型酸衍生的醚酯化合物，含有这种醚酯化合物的润滑油基础油以及含有这种醚酯化合物的润滑油组合物。方法可以包括制备和配制含有从新型酸衍生的醚酯化合物的组合物。