1-Aza-9(10H)-acridon | 64021-63-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Aza-9(10H)-acridon
• 英文别名: Pyrido<3.2-b>-5H-chinolinon-(10)；benzo[b][1,5]naphthyridin-10(5H)-one；5H-benzo[b][1,5]naphthyridin-10-one；Azaacridone；5H-benzo[b][1,5]naphthyridin-10-one
• CAS: 64021-63-2
• 化学式: C₁₂H₈N₂O
• 分子量: 196.208
• InChiKey: GBLDSZMDSYLZOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Aza-9(10H)-acridon 在 草酰氯 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 为溶剂， 生成 1-Aza-9-chloracridin
  参考文献：
  名称：

  Synthesis and Complexation Behavior of Indenyl and Cyclopentadienyl Ligands Functionalized with a Naphthyridine Unit

  摘要：

  Lithium indenide (Li-Ind) or cyclopentadienide (Li-Cp) derivatives react as nucleophiles with 8-(methylsulfinyl)-1,5-naphthyridine (Naph), leading to donor-functionalized ligands Ind(Naph) or Cp-Naph, respectively. The new ligands comprise two N-donor atoms, which, for geometric reasons, cannot bind to the same metal atom. In complexes, where the metal atom is bound by the Cp or Ind moiety, the N5-donor atom is located in a distal position. The coordination behavior to Rh or Zr metal centers has been investigated. The Cp-based ligands show the expected chelating coordination mode with eta(5)-Cp and N coordination, whereas the indenyl units act as dihapto, trihapto, or pentahapto ligands. The dinuclear Rh(I) complex 12 shows a rare coordination geometry with two eta(3) ligands bridging a Rh-2(CO)(3) fragment.

  DOI：

  10.1021/om2009638
• 作为产物：
  描述：

  N-(3-pyridyl)anthranilic acid 以75%的产率得到
  参考文献：
  名称：

  DENNY W. A.; ATWELL G. J.; CAIN B. F., J. MED. CHEM. , 1977, 20, NO 10, 1242-1246

  摘要：

  DOI：

文献信息

• Synthesis and Complexation Behavior of Indenyl and Cyclopentadienyl Ligands Functionalized with a Naphthyridine Unit
  作者：David Sieb、Katrin Schuhen、Michael Morgen、Heike Herrmann、Hubert Wadepohl、Nigel T. Lucas、Robert W. Baker、Markus Enders

  DOI：10.1021/om2009638

  日期：2012.1.9

  Lithium indenide (Li-Ind) or cyclopentadienide (Li-Cp) derivatives react as nucleophiles with 8-(methylsulfinyl)-1,5-naphthyridine (Naph), leading to donor-functionalized ligands Ind(Naph) or Cp-Naph, respectively. The new ligands comprise two N-donor atoms, which, for geometric reasons, cannot bind to the same metal atom. In complexes, where the metal atom is bound by the Cp or Ind moiety, the N5-donor atom is located in a distal position. The coordination behavior to Rh or Zr metal centers has been investigated. The Cp-based ligands show the expected chelating coordination mode with eta(5)-Cp and N coordination, whereas the indenyl units act as dihapto, trihapto, or pentahapto ligands. The dinuclear Rh(I) complex 12 shows a rare coordination geometry with two eta(3) ligands bridging a Rh-2(CO)(3) fragment.
• DENNY W. A.; ATWELL G. J.; CAIN B. F., J. MED. CHEM. <JMCM-AR>, 1977, 20, NO 10, 1242-1246
  作者：DENNY W. A.、 ATWELL G. J.、 CAIN B. F.

  DOI：——

  日期：——