(2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-(4-methoxy-benzyloxymethyl)-6-((2R,3R,4S,5R)-3,4,5-tris-benzyloxy-6-oxo-piperidin-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester | 851220-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: (2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-(4-methoxy-benzyloxymethyl)-6-((2R,3R,4S,5R)-3,4,5-tris-benzyloxy-6-oxo-piperidin-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester
• 英文别名: tert-butyl (2R,3R,4S,5R,6R)-2-[(4-methoxyphenyl)methoxymethyl]-6-[[(2R,3R,4S,5R)-6-oxo-3,4,5-tris(phenylmethoxy)piperidin-2-yl]methoxy]-3,4,5-tris(phenylmethoxy)piperidine-1-carboxylate
• CAS: 851220-46-7
• 化学式: C₆₇H₇₄N₂O₁₂
• 分子量: 1099.33
• InChiKey: AWGLRQICCYPVSK-RSLYRBHLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.9
• 重原子数：
  81
• 可旋转键数：
  28
• 环数：
  9.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  142
• 氢给体数：
  1
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-(4-methoxy-benzyloxymethyl)-6-((2R,3R,4S,5R)-3,4,5-tris-benzyloxy-6-oxo-piperidin-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester 、 二碳酸二叔丁酯 在 4-二甲氨基吡啶 作用下， 以 乙腈 为溶剂， 以92%的产率得到tert-butyl (2R,3R,4S,5R)-2-[[(2R,3R,4S,5R,6R)-6-[(4-methoxyphenyl)methoxymethyl]-1-[(2-methylpropan-2-yl)oxycarbonyl]-3,4,5-tris(phenylmethoxy)piperidin-2-yl]oxymethyl]-6-oxo-3,4,5-tris(phenylmethoxy)piperidine-1-carboxylate
  参考文献：
  名称：

  Synthesis of N-protected azaoligosaccharides and their cyclic derivatives

  摘要：

  Azaoligosaccharides are prepared through the glycosylation of nojirimycin derivatives with catalytic amounts of TMSOTf. Also, the 1-6', V-6-cyclic azadisaccharides are successfully synthesized, and their one-pot syntheses are demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.02.057
• 作为产物：
  描述：

  (3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-6-trimethylsilanyloxymethyl-piperidin-2-one 、 (2R,3R,4S,5R)-3,4,5-Tris-benzyloxy-2-(4-methoxy-benzyloxymethyl)-6-trimethylsilanyloxy-piperidine-1-carboxylic acid tert-butyl ester 在 三氟甲磺酸三甲基硅酯 作用下， 以 四氢呋喃 为溶剂， 以90%的产率得到(2R,3R,4S,5R,6R)-3,4,5-Tris-benzyloxy-2-(4-methoxy-benzyloxymethyl)-6-((2R,3R,4S,5R)-3,4,5-tris-benzyloxy-6-oxo-piperidin-2-ylmethoxy)-piperidine-1-carboxylic acid tert-butyl ester
  参考文献：
  名称：

  Synthesis of N-protected azaoligosaccharides and their cyclic derivatives

  摘要：

  Azaoligosaccharides are prepared through the glycosylation of nojirimycin derivatives with catalytic amounts of TMSOTf. Also, the 1-6', V-6-cyclic azadisaccharides are successfully synthesized, and their one-pot syntheses are demonstrated. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2005.02.057