Bn(-2)Fuc3Ac4Ac(a1-3)[Gal2Ac3Ac4Ac6Ac(b1-4)][TrocNH(-2d)][Bn(-6)]Glc(b)-O-C(NH)CCl3 | 212713-64-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Bn(-2)Fuc3Ac4Ac(a1-3)[Gal2Ac3Ac4Ac6Ac(b1-4)][TrocNH(-2d)][Bn(-6)]Glc(b)-O-C(NH)CCl3
• 英文别名: [(2R,3S,4S,5R,6S)-3,4,5-triacetyloxy-6-[(2R,3S,4R,5R,6S)-4-[(2S,3S,4R,5R,6S)-4,5-diacetyloxy-6-methyl-3-phenylmethoxyoxan-2-yl]oxy-2-(phenylmethoxymethyl)-6-(2,2,2-trichloroethanimidoyl)oxy-5-(2,2,2-trichloroethoxycarbonylamino)oxan-3-yl]oxyoxan-2-yl]methyl acetate
• CAS: 212713-64-9
• 化学式: C₄₉H₅₈Cl₆N₂O₂₂
• 分子量: 1239.72
• InChiKey: VJIHQVXDEPIISO-XTHOVXHISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  79
• 可旋转键数：
  29
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  294
• 氢给体数：
  2
• 氢受体数：
  23

反应信息

• 作为反应物：
  描述：

  Acetic acid (2R,3S,4S,5R,6S)-5-benzyloxy-2-benzyloxymethyl-4-hydroxy-6-((2R,3S,4S,5R,6R)-4,5,6-tris-benzyloxy-2-benzyloxymethyl-tetrahydro-pyran-3-yloxy)-tetrahydro-pyran-3-yl ester 、 Bn(-2)Fuc3Ac4Ac(a1-3)[Gal2Ac3Ac4Ac6Ac(b1-4)][TrocNH(-2d)][Bn(-6)]Glc(b)-O-C(NH)CCl3 在 三氟化硼乙醚 作用下， 以 二氯甲烷 为溶剂， 以60%的产率得到
  参考文献：
  名称：

  Synthesis of Lewis a and Lewis X Pentasaccharides Based on N-Trichloroethoxycarbonyl Protection

  摘要：

  Thexyldimethylsilyl 4,6-O-benzylidene-2-deoxy-2-trichloroethoxycarbonylamino-beta-D-glucopyranoside (4), having the 3-hydroxy group unprotected, is a versatile starting material for the synthesis of glucosamine containing oligosaccharides. Thus, reaction with galactosyl donor 5 or fucosyl donor 6 afforded the desired beta(1-3)- and alpha(1-3)-linked disaccharides 7 and 8, respectively, in high yields, Reductive opening of the benzylidene moieties in 7 and 8 gave access to the 4-hydroxy groups in 9 and 10. Ensuing fucosylation of 9 or galactosylation of 10 led to Lewis A (Le(a)) and Lewis X (Le(x)) trisaccharide building blocks 13 and 14, respectively. Their transformation into glycosyl donors 19 and 20 and subsequent reaction with 3b-O-unprotected lactose derivative 23 as acceptor furnished the Le(a)- and Le(x) pentasaccharide precursors 24 and 25. Exchange of the N-trichloroethoxycarbonyl group for an N-acetyl group and removal of the O-benzyl and O-acetyl protective groups afforded the desired Le(a)- and Lex-pentasaccharides 1 and 2.

  DOI：

  10.1080/07328309808002349
• 作为产物：
  描述：

  C₄₁H₅₆Cl₃NO₁₃Si 在 盐酸 、 三氟化硼乙醚 、 四丁基氟化铵 、 sodium cyanoborohydride 、 溶剂黄146 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 为溶剂， 反应 194.25h， 生成 Bn(-2)Fuc3Ac4Ac(a1-3)[Gal2Ac3Ac4Ac6Ac(b1-4)][TrocNH(-2d)][Bn(-6)]Glc(b)-O-C(NH)CCl3
  参考文献：
  名称：

  Synthesis of Lewis a and Lewis X Pentasaccharides Based on N-Trichloroethoxycarbonyl Protection

  摘要：

  Thexyldimethylsilyl 4,6-O-benzylidene-2-deoxy-2-trichloroethoxycarbonylamino-beta-D-glucopyranoside (4), having the 3-hydroxy group unprotected, is a versatile starting material for the synthesis of glucosamine containing oligosaccharides. Thus, reaction with galactosyl donor 5 or fucosyl donor 6 afforded the desired beta(1-3)- and alpha(1-3)-linked disaccharides 7 and 8, respectively, in high yields, Reductive opening of the benzylidene moieties in 7 and 8 gave access to the 4-hydroxy groups in 9 and 10. Ensuing fucosylation of 9 or galactosylation of 10 led to Lewis A (Le(a)) and Lewis X (Le(x)) trisaccharide building blocks 13 and 14, respectively. Their transformation into glycosyl donors 19 and 20 and subsequent reaction with 3b-O-unprotected lactose derivative 23 as acceptor furnished the Le(a)- and Le(x) pentasaccharide precursors 24 and 25. Exchange of the N-trichloroethoxycarbonyl group for an N-acetyl group and removal of the O-benzyl and O-acetyl protective groups afforded the desired Le(a)- and Lex-pentasaccharides 1 and 2.

  DOI：

  10.1080/07328309808002349