1,4-Bis-(3-benzyloxy-5-hexyloxy-4-methoxy-phenyl)-butane-1,4-dione | 1027181-47-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,4-Bis-(3-benzyloxy-5-hexyloxy-4-methoxy-phenyl)-butane-1,4-dione
• 英文别名: 1,4-Bis(3-hexoxy-4-methoxy-5-phenylmethoxyphenyl)butane-1,4-dione
• CAS: 1027181-47-0
• 化学式: C₄₄H₅₄O₈
• 分子量: 710.908
• InChiKey: MPQRQPJVGVZNFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.3
• 重原子数：
  52
• 可旋转键数：
  25
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,4-Bis-(3-benzyloxy-5-hexyloxy-4-methoxy-phenyl)-butane-1,4-dione 在 sodium tetrahydroborate 、 三氟乙酸 作用下， 以 乙醇 、 氯仿 为溶剂， 反应 2.83h， 生成 (2R,5S)-2,5-Bis-(3-benzyloxy-5-hexyloxy-4-methoxy-phenyl)-tetrahydro-furan
  参考文献：
  名称：

  Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

  摘要：

  This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.

  DOI：

  10.1016/0223-5234(96)89161-6
• 作为产物：
  描述：

  3,5-二羟基-4-甲氧基苯甲酸甲酯 在 盐酸 、 sodium hydroxide 、 三甲基氯硅烷 、 甲基锂 、 copper(II) bis(trifluoromethanesulfonate) 、 potassium carbonate 、 三乙胺 、 sodium iodide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 17.42h， 生成 1,4-Bis-(3-benzyloxy-5-hexyloxy-4-methoxy-phenyl)-butane-1,4-dione
  参考文献：
  名称：

  Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups

  摘要：

  This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.

  DOI：

  10.1016/0223-5234(96)89161-6

文献信息

• Synthesis and PAF antagonist activity of some 2,5-diaryltetrahydrofurans incorporating PAF-like functional groups
  作者：S Smith、G.J. Blackwell、D.A. Demaine、L.G. Garland、H.F. Hodson、R.M. Hyde、A.J. Parke、V.S. Rose、D.A. Sawyer、L Tilling

  DOI：10.1016/0223-5234(96)89161-6

  日期：1996.1

  This paper describes the synthesis and structure-activity relationships of a series of 2,5-diaryltetrahydrofurans, as specific and potent antagonists at the rabbit washed platelet activating factor (PAF) receptor. The methoxyl groups in the known PAF antagonist L-652,731 were replaced with functional groups present in PAF and in the 'PAF-like' antagonists. Activity was generally retained or enhanced when one aryl ring in L-652,731 was elaborated; however incorporation of these functional groups into both of the aryl rings greatly reduced or abolished activity. These results are discussed in relation to a putative model for the PAF receptor.