3-(2-(2-methoxyethoxy)ethoxy)propan-1-ol | 100688-48-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-(2-(2-methoxyethoxy)ethoxy)propan-1-ol
• 英文别名: 3-[2-(2-Methoxyethoxy)ethoxy]propan-1-OL；3-[2-(2-methoxyethoxy)ethoxy]propan-1-ol
• CAS: 100688-48-0
• 化学式: C₈H₁₈O₄
• 分子量: 178.229
• InChiKey: QBHPYEIJQRUYLB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(2-(2-methoxyethoxy)ethoxy)propan-1-ol 在 di-tert-butyl (E)-azodicarboxylate 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 反应 19.0h， 生成 1-allyl-6-chloro-3-(3-(2-(2-methoxyethoxy)ethoxy)propyl)-1,3,4,9-tetrahydro-[1,2,6]thiadiazino[4,3-g]indole 2,2-dioxide
  参考文献：
  名称：

  WO2023/64152

  摘要：

  公开号：
• 作为产物：
  描述：

  13-phenyl-2,5,8,12-tetraoxatridecane 在 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、103.42 kPa 条件下， 以450 mg的产率得到3-(2-(2-methoxyethoxy)ethoxy)propan-1-ol
  参考文献：
  名称：

  WO2023/64152

  摘要：

  公开号：

文献信息

• GRAPHENE COMPOUND AND MANUFACTURING METHOD THEREOF, ELECTROLYTE, AND POWER STORAGE DEVICE
  申请人：SEMICONDUCTOR ENERGY LABORATORY CO., LTD.

  公开号：US20180108944A1

  公开（公告）日：2018-04-19

  To provide a graphene compound having an insulating property and an affinity for lithium ions. To increase the molecular weight of a substituent included in a graphene compound. To provide a graphene compound including a chain group containing an ether bond or an ester bond. To provide a graphene compound including a substituent containing one or more branches. To provide a graphene compound including a substituent including at least one of an ester bond and an amide bond.

  提供具有绝缘性和对锂离子亲和性的石墨烯化合物。增加石墨烯化合物中包含的取代基的分子量。提供包含含有醚键或酯键的链基团的石墨烯化合物。提供包含含有一个或多个支链的取代基的石墨烯化合物。提供包含至少一种酯键和酰胺键的取代基的石墨烯化合物。
• COLORED CURABLE COMPOSITION, COLOR FILTER AND METHOD FOR PRODUCTION THEREOF, AND SOLID IMAGING ELEMENT
  申请人：FUJIFILM Corporation

  公开号：EP2333608A1

  公开（公告）日：2011-06-15

  A colored curable composition with which a coating film having excellent uniformity and surface planarity can be formed even when the support (substrate) has irregularities, and which exhibits excellent developability, and which is capable of forming a high-resolution colored pattern, is provided. The colored curable composition includes: (A) a polymer that contains a structural unit having a carboxyl group bonded to a main chain thereof via a linking group containing an ester group; (B) a photopolymerization initiator; (C) a polymerizable compound; (D) a pigment; and (E) a dispersant containing a phosphoric acid group.

  本发明提供了一种彩色可固化组合物，使用该组合物即使在支撑物（基底）不规则的情况下也能形成均匀性和表面平面度极佳的涂膜，并且表现出极佳的显影性，还能形成高分辨率的彩色图案。彩色可固化组合物包括(A) 含有结构单元的聚合物，该结构单元具有通过含有酯基的连接基团与主链键合的羧基；(B) 光聚合引发剂；(C) 可聚合化合物；(D) 颜料；以及 (E) 含磷酸基团的分散剂。
• Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides
  申请人：Arvinas, Inc.

  公开号：US10723717B2

  公开（公告）日：2020-07-28

  The present disclosure relates to bifunctional compounds, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (RAF, such as c-RAF, A-RAF and/or B-RAF; the target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon, Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein RAF, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein, or the constitutive activation of the target protein, are treated or prevented with compounds and compositions of the present disclosure.

  本公开涉及双功能化合物，它们可用作快速加速纤维肉瘤（RAF，如c-RAF、A-RAF和/或B-RAF；靶蛋白）的调节剂。特别是，本公开内容涉及双功能化合物，其一端含有与相应 E3 泛素连接酶结合的 Von Hippel-Lindau、cereblon、抑制细胞凋亡蛋白或小鼠双敏同源物 2 配体，另一端含有与靶蛋白 RAF 结合的分子，从而将靶蛋白置于泛素连接酶附近，以实现对靶蛋白的降解（和抑制）。本公开物具有与降解/抑制靶蛋白相关的广泛药理活性。本公开的化合物和组合物可以治疗或预防由于靶蛋白的聚集或积聚或靶蛋白的组成性激活而导致的疾病或失调。
• WO2020210521A5
  申请人：——

  公开号：WO2020210521A5

  公开（公告）日：2023-04-14
• COMPOSITIONS AND METHODS FOR INCREASING MUSCLE MASS AND OXIDATIVE METABOLISM
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：EP3952849A2

  公开（公告）日：2022-02-16