3-Deoxy-l-manno-octulosonic acid | 455269-82-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Deoxy-l-manno-octulosonic acid
• 英文别名: (4S,5S,6S,7S)-4,5,6,7,8-pentahydroxy-2-oxooctanoic acid
• CAS: 455269-82-6
• 化学式: C₈H₁₄O₈
• 分子量: 238.19
• InChiKey: KYQCXUMVJGMDNG-RRNYIBRJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.6
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  156
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  、 3-deoxy-D-manno-oct-2-ulopyranosonic acid 、 、 、 以 水 为溶剂， 生成 3-Deoxy-l-manno-octulosonic acid
  参考文献：
  名称：

  Ketoaldonic acids having formed stereogenic centers of R configuration: methods and compositions

  摘要：

  本发明提供了一种具有形成立体异构中心的R构型的酮醛酸，例如八烯酸或九烯酸，以及其合成方法。

  公开号：

  US06353095B1

文献信息

• [EN] SELECTION BY MIRROR IMAGE DISPLAY<br/>[FR] SELECTION PAR DISPOSITIF D'AFFICHAGE MIROIR
  申请人：SCRIPPS RESEARCH INST

  公开号：WO2002067860A2

  公开（公告）日：2002-09-06

  Non-naturally occurring binders to cell surface carbohydrates and sugars are identified by a screening process that employs immobilized enantiomers of such cell surface carbohydrates and sugars. Preferred non-naturally occurring binders include D- peptides and L- nucleic acids and are resistance to enzymatic degradation and clearance. Single-chain Fab sequences that bind to sialic acid and KDO in nano-molar affinity were identified by this process. Exemplary screening procedures employed D-KDO, L-sialic acid and an L-sialo-disaccharide have been attached to a solid support for selection of high-affinity binders.
• Ketoaldonic acids having formed stereogenic centers of R configuration: methods and compositions
  申请人：The Scripps Research Institute

  公开号：US06353095B1

  公开（公告）日：2002-03-05

  The present invention provides a ketoaldonic acid such as an octulosonic or nonulosonic acid having a formed stereogenic center of R configuration, as well as methods of synthesizing the same.

  本发明提供了一种具有形成立体异构中心的R构型的酮醛酸，例如八烯酸或九烯酸，以及其合成方法。