4-thien-2-oyl-3-cyanofuroxan | 1147336-13-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 噻吩类
• 英文名称: 4-thien-2-oyl-3-cyanofuroxan
• 英文别名: 4-thienoyl-3-cyanofuroxan；2-oxido-4-(thiophene-2-carbonyl)-1,2,5-oxadiazol-2-ium-3-carbonitrile
• CAS: 1147336-13-7
• 化学式: C₈H₃N₃O₃S
• 分子量: 221.196
• InChiKey: VABMHJHGQFYWBF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  121
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  4-thien-2-oylfuroxan-3-carbaldehyde oxime 在 氯化亚砜 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以79%的产率得到4-thien-2-oyl-3-cyanofuroxan
  参考文献：
  名称：

  Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents

  摘要：

  The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity. Published by Elsevier Ltd.

  DOI：

  10.1016/j.tetlet.2009.01.120

文献信息

• [EN] OXADIAZOLE-2-OXIDES AS ANTISCHISTOSOMAL AGENTS<br/>[FR] OXADIAZOLE-2-OXYDES EN TANT QU'AGENTS ANTISCHISTOSOMIAUX
  申请人：US HEALTH

  公开号：WO2010019772A3

  公开（公告）日：2010-08-26
• Synthesis of oxadiazole-2-oxide analogues as potential antischistosomal agents
  作者：Ganesha Rai、Craig J. Thomas、William Leister、David J. Maloney

  DOI：10.1016/j.tetlet.2009.01.120

  日期：2009.4

  The synthesis of several 1,2,5-oxadiazole-2-oxide (Furoxan) analogues is described herein. These compounds were prepared in an effort to probe the SAR around the phenyl substituent and oxadiazole core for our studies toward thioredoxin-glutathione reductase (TGR) inhibition and antischistosomal activity. Published by Elsevier Ltd.