A dentifrice composition comprises a toothpaste carrier having a pH of about 7 to about 10 and a calcium ion source and a fluoride ion source wherein the calcium ion source is unencapsulated and the fluoride ion source is encapsulated or coated in a coating impermeable to the toothpaste carrier. The coating degrades to release fluoride ions when mechanically agitated by a toothbrush in an oral cavity surface. In a second embodiment, the dentifrice composition comprises an aqueous toothpaste carrier having a pH of about 7 to about 10 with an unencapsulated calcium ion source and a fluoride ion source having a pH of between 3 to less than 7 wherein the fluoride ion source is encapsulated in a first (or inner) impermeable coating adapted to degrade to release the fluoride ions in the presence of a toothpaste carrier. The first coating is encased in a second (or outer) impermeable coating adapted to resist degradation in the presence of the toothpaste carrier and to mechanically degrade to expose the first (or inner coating) which degrades to release the fluoride ions in response to application of the dentifrice composition to an oral cavity surface.
一种牙膏组合物包括 pH 值约为 7 至 10 的牙膏载体、
钙离子源和
氟离子源,其中
钙离子源未封装,
氟离子源封装或涂覆在牙膏载体不渗透的涂层中。当牙刷在口腔表面进行机械搅拌时,涂层降解释放
氟离子。在第二个实施方案中,牙膏组合物包括 pH 值约为 7 到 10 的
水性牙膏载体,其中含有未封装的
钙离子源和 pH 值在 3 到小于 7 之间的
氟离子源,其中
氟离子源封装在第一层(或内部)防渗涂层中,该涂层适于在牙膏载体存在时降解以释放
氟离子。第一层涂层封装在第二层(或外层)防渗涂层中,第二层防渗涂层适于在牙膏载体存在的情况下抵抗降解并机械降解以暴露第一层(或内层),第一层(或内层)降解以在牙膏组合物应用于口腔表面时释放
氟离子。