5-(Furan-3-yl)-1,3-oxazole-2(3H)-thione | 832077-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-(Furan-3-yl)-1,3-oxazole-2(3H)-thione
• 英文别名: 5-(furan-3-yl)-3H-1,3-oxazole-2-thione
• CAS: 832077-52-8
• 化学式: C₇H₅NO₂S
• 分子量: 167.19
• InChiKey: AYUOHDHEHHJFPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NOVEL N-OXIDES OF FURANYL-OXADIAZOLYL-DIAZABICYCLONONANE DERIVATIVES AND THEIR MEDICAL USE<br/>[FR] NOUVEAUX N-OXYDES DE DÉRIVÉS DE FURANYL-OXADIAZOLYL-DIAZABICYCLONONANE ET LEUR UTILISATION MÉDICALE
  申请人：NEUROSEARCH AS

  公开号：WO2010086280A1

  公开（公告）日：2010-08-05

  This invention relates to novel N-oxides of certain furanyl-oxadiazolyl-diazabicyclononane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  这项发明涉及某些呋喃基-噁唑啉基-双氮杂双环庚烷衍生物的新型N-氧化物及其在制备药物组合物中的应用。该发明的化合物被发现是尼古丁乙酰胆碱受体的胆碱能配体，同时也是单胺受体和转运体的调节剂。由于它们的药理特性，该发明的化合物可能对治疗与中枢神经系统（CNS）的胆碱能系统、外周神经系统（PNS）、平滑肌收缩有关的疾病或障碍、内分泌疾病或障碍、神经退行性疾病或障碍、炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状等疾病或障碍具有用处。