1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 4-pyridylmethylidene hydrazide | 376385-07-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 4-pyridylmethylidene hydrazide
• 英文别名: 1-hexyl-4-hydroxy-2-oxo-N-(pyridin-4-ylmethylideneamino)quinoline-3-carboxamide
• CAS: 376385-07-8
• 化学式: C₂₂H₂₄N₄O₃
• 分子量: 392.458
• InChiKey: JGZNGQCDRIPQDV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  94.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 4-pyridylmethylidene hydrazide 在 溴 作用下， 以 溶剂黄146 为溶剂， 生成
  参考文献：
  名称：

  4-hydroxy-2-quinolones. 200*. Bromination of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridinylmethylene hydrazides

  摘要：

  The behavior of 1-R-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid pyridinylmethylene-hydrazides under bromination conditions using molecular bromine has been studied. It has been found that the 1-N-allyl derivative is characteristically halocyclized to the corresponding oxazolo[3,2-a]quinoline, whereas the 1-N-hexyl-substituted acylhydrazone is unexpectedly brominated in the azomethine fragment.

  DOI：

  10.1007/s10593-011-0868-z

文献信息

• 4-hydroxy-2-quinolones. 203*. Reaction of 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 4-pyridylmethylidene hydrazide with bromine
  作者：I. V. Ukrainets、E. V. Mospanova、S. V. Shishkina

  DOI：10.1007/s10593-012-1122-z

  日期：2012.11

  It has been shown experimentally that upon the reaction of 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid 4-pyridylmethylidene hydrazide with molecular bromine in glacial acetic acid not only the azomethine carbon atom is brominated, but also the position 6 of the quinolone ring.