3-(2-Ethoxyethyl)-2-methyl-2-phenylchromene | 1228299-29-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: 3-(2-Ethoxyethyl)-2-methyl-2-phenylchromene
• 英文别名: 3-(2-ethoxyethyl)-2-methyl-2-phenylchromene
• CAS: 1228299-29-3
• 化学式: C₂₀H₂₂O₂
• 分子量: 294.393
• InChiKey: IIBWQFPPGLWCNK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  6-(ethoxymethylidene)cyclohexa-2,4-dien-1-one 、 1-methyl-1-phenylmethylenecyclopropane 在 scandium tris(trifluoromethanesulfonate) 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 生成 3-(2-Ethoxyethyl)-2-methyl-2-phenylchromene
  参考文献：
  名称：

  Lewis Acid Catalyzed Cycloaddition of Methylenecyclopropanes with Salicylaldehydes

  摘要：

  Lewis acid catalyzed cycloaddition of methylenecyclopropanes (MCPs) with o-quinonemethide analogues, derived from the corresponding salicylaldehydes and CH(OEt)(3), produces the corresponding cycloadducts 3 in moderate to high yields at room temperature (20 degrees C). Moreover, the compounds 3 can be transformed to the indene derivatives 5 at high temperature. Plausible mechanisms have been proposed on the basis of control experiments.

  DOI：

  10.1021/ol100814a

文献信息

• Lewis Acid Catalyzed Cycloaddition of Methylenecyclopropanes with Salicylaldehydes
  作者：Min Jiang、Min Shi

  DOI：10.1021/ol100814a

  日期：2010.6.4

  Lewis acid catalyzed cycloaddition of methylenecyclopropanes (MCPs) with o-quinonemethide analogues, derived from the corresponding salicylaldehydes and CH(OEt)(3), produces the corresponding cycloadducts 3 in moderate to high yields at room temperature (20 degrees C). Moreover, the compounds 3 can be transformed to the indene derivatives 5 at high temperature. Plausible mechanisms have been proposed on the basis of control experiments.