hesperetin 7-O-phosphate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 英文名称: hesperetin 7-O-phosphate
• 英文别名: [(2S)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-2,3-dihydrochromen-7-yl] dihydrogen phosphate
• 化学式: C₁₆H₁₅O₉P
• 分子量: 382.263
• InChiKey: WEVRRXRHNBYSDG-AWEZNQCLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  143
• 氢给体数：
  4
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  橙皮素 在 phosphotransferase from Bacillus subtilis 、 5’-三磷酸腺苷 、 sodium chloride 、 magnesium chloride 作用下， 以 二甲基亚砜 为溶剂， 反应 1.0h， 生成 hesperetin 7-O-phosphate 、 hesperetin 3′-O-phosphate
  参考文献：
  名称：

  Discovery of a novel phosphotransferase from Bacillus subtilis that phosphorylates a broad spectrum of flavonoids

  摘要：

  DOI：

  10.1016/j.foodchem.2022.134001

文献信息

• METHOD OF BIOTRANSFORMATION OF BENZOPYRONE COMPOUNDS INTO THE CORRESPONDING PHOSPHATE-CONJUGATED DERIVATIVES
  申请人：National Taiwan University

  公开号：US20170305944A1

  公开（公告）日：2017-10-26

  The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase activity, and also a microorganism comprising a nucleic acid sequence that encodes the polypeptide, for the preparation of phosphate-conjugated derivatives of benzopyrone compounds. The hydrophilic property of the benzopyrone compounds is enhanced after catalyzed by the benzopyrone phosphate synthetase of the present invention.

  本发明涉及一种生物转化过程，通过一种具有苯并吡喃磷酸合酶活性的分离多肽实现，并且包括一种编码该多肽的核酸序列的微生物，用于制备苯并吡喃化合物的磷酸共轭衍生物。经本发明的苯并吡喃磷酸合酶催化后，苯并吡喃化合物的亲水性质得到增强。
• Method of biotransformation of benzopyrone compounds into the corresponding phosphate-conjugated derivatives
  申请人：National Taiwan University

  公开号：US10421768B2

  公开（公告）日：2019-09-24

  The present invention is related to a biotransformation process, effected by means of an isolated polypeptide possessing benzopyrone phosphate synthetase activity, and also a microorganism comprising a nucleic acid sequence that encodes the polypeptide, for the preparation of phosphate-conjugated derivatives of benzopyrone compounds. The hydrophilic property of the benzopyrone compounds is enhanced after catalyzed by the benzopyrone phosphate synthetase of the present invention.

  本发明涉及一种生物转化过程，该过程通过一种具有吡喃苯酮磷酸合成酶活性的分离多肽和一种包含编码该多肽的核酸序列的微生物来实现，用于制备吡喃苯酮化合物的磷酸结合衍生物。经本发明的苯并吡喃酮磷酸合成酶催化后，苯并吡喃酮化合物的亲水性增强。
• Discovery of a novel phosphotransferase from Bacillus subtilis that phosphorylates a broad spectrum of flavonoids
  作者：Chen Hsu、Hsin-Ya Tsai、Chi-Fon Chang、Chien-Chih Yang、Nan-Wei Su

  DOI：10.1016/j.foodchem.2022.134001

  日期：2023.1