1-(methanesulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-(methanesulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
• 英文别名: 1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid；1-methanesulfonyl-3,4-dihydro-2H-quinoline-6-carboxylic acid；1-methylsulfonyl-3,4-dihydro-2H-quinoline-6-carboxylic acid
• 化学式: C₁₁H₁₃NO₄S
• mdl: MFCD06655754
• 分子量: 255.295
• InChiKey: NIVCCCWZONRAOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.363
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-bromo-1-(methylsulfonyl)-1,2,3,4-tetrahydroquinoline 、 一氧化碳 在 dicobalt octacarbonyl potassium carbonate 、 methyloxirane 、 氢氧化钾 作用下， 以 甲醇 为溶剂， 反应 6.0h， 以86%的产率得到1-(methanesulfonyl)-1,2,3,4-tetrahydroquinoline-6-carboxylic acid
  参考文献：
  名称：

  Synthesis of heteroaromatic carboxylic acids by carbonylation of hetaryl halides with catalysts based on cobalt carbonyl modified with epoxides

  摘要：

  A new method for the synthesis of heteroaromatic acids and their derivatives (esters and salts) by carbonylation of the corresponding halides was developed. Hetaryl halides were activated in alcoholic-alkali medium by highly active catalytic systems based on cobalt carbonyl modified with epoxides, developed previously for carbonylation of aryl halides.

  DOI：

  10.1134/s1070427207040106

文献信息

• (Hetero)aryl-substituted-piperidinyl derivatives, a process for their preparation and pharmaceutical compositions containing them
  申请人：LES LABORATOIRES SERVIER

  公开号：US10654849B2

  公开（公告）日：2020-05-19

  Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.

  式(I)化合物： 其中 R1、R2、J、K、L、n 和 W 如说明中所定义。 含有相同成分的医药产品，可用于治疗需要促凋亡剂和/或抗增生剂的病症。
• Heterocyclic compounds as RSV inhibitors
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US10759816B2

  公开（公告）日：2020-09-01

  The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit Respiratory Syncytial Virus (RSV). The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from RSV infection. The invention also relates to methods of treating an RSV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

  本发明公开了式（I）化合物或其药学上可接受的盐、酯或原药： 其可抑制呼吸道合胞病毒（RSV）。本发明进一步涉及包含上述化合物的药物组合物，用于给受 RSV 感染的患者用药。本发明还涉及通过施用包含本发明化合物的药物组合物治疗受试者 RSV 感染的方法。
• HETEROCYCLIC COMPOUNDS AS RSV INHIBITORS
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：EP3402799A1

  公开（公告）日：2018-11-21
• NEW (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Les Laboratoires Servier

  公开号：EP3468971A1

  公开（公告）日：2019-04-17
• (HETERO)ARYL-SUBSTITUTED-PIPERIDINYL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：LES LABORATOIRES SERVIER

  公开号：US20190144449A1

  公开（公告）日：2019-05-16

  Compounds of formula (I): wherein R 1 , R 2 , J, K, L, n and W are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.