2-(2-乙酰苯氧基)乙酰胺 | 445232-49-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 2-(2-乙酰苯氧基)乙酰胺
• 中文别名: 2-(2-乙酰基苯氧基)乙酰胺
• 英文名称: 2-(2-Acetylphenoxy)acetamide
• CAS: 445232-49-5
• 化学式: C₁₀H₁₁NO₃
• mdl: MFCD02245031
• 分子量: 193.202
• InChiKey: UXVUMQDBMPXNKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  69.4
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  2-(2-乙酰苯氧基)乙酰胺 在 三乙基硅烷 、 aluminium(III) triflate 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以60%的产率得到5-methyl-4,5-dihydrobenzo[f ][1,4]oxazepin-3(2H)-one
  参考文献：
  名称：

  Synthesis of Dihydrobenzoheterocycles through Al(OTf)₃-Mediated Cascade Cyclization and Ionic Hydrogenation

  摘要：

  A facile and versatile synthesis of dihydrobenzoheterocycles via Al(OTf)(3)-mediated cascade cyclization and ionic hydrogenation has been developed. The reaction is applicable to a wide range of substrates with various functional groups to afford the corresponding products in good yields.

  DOI：

  10.1021/jo501824z

文献信息

• A pharmaceutical composition containing a benzofuran-carboxamide derivative as the active ingredient
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP0045473A1

  公开（公告）日：1982-02-10

  A pharmaceutical composition, specifically a muscle relaxant acting at the same time as an anti-inflammatory and analgesic agent which composition comprises pharmaceutically acceptable carrier(s) and a benzo[b]furancarboxamide derivative represented by the general formula: wherein R represents a halogen atom, an alkyl group having 1 - 5 carbon atoms or an alkoxy group having 1 - 5 carbon atoms.

  一种药物组合物，特别是一种同时具有消炎和镇痛作用的肌肉松弛剂，该组合物由药学上可接受的载体和通式所代表的苯并[b]呋喃甲酰胺衍生物组成： 其中 R 代表卤素原子、1-5 个碳原子的烷基或 1-5 个碳原子的烷氧基。
• US4353923A
  申请人：——

  公开号：US4353923A

  公开（公告）日：1982-10-12
• Synthesis of Dihydrobenzoheterocycles through Al(OTf)₃-Mediated Cascade Cyclization and Ionic Hydrogenation
  作者：Yulin Tian、Xiaojian Wang、Qiong Xiao、Chenbin Sun、Dali Yin

  DOI：10.1021/jo501824z

  日期：2014.10.17

  A facile and versatile synthesis of dihydrobenzoheterocycles via Al(OTf)(3)-mediated cascade cyclization and ionic hydrogenation has been developed. The reaction is applicable to a wide range of substrates with various functional groups to afford the corresponding products in good yields.