8-nitro-4-piperidin-1-yl-quinoline | 714279-18-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 8-nitro-4-piperidin-1-yl-quinoline
• 英文别名: 8-Nitro-4-(piperidin-1-yl)quinoline；8-nitro-4-piperidin-1-ylquinoline
• CAS: 714279-18-2
• 化学式: C₁₄H₁₅N₃O₂
• mdl: MFCD05819367
• 分子量: 257.292
• InChiKey: GGGFGABKBYDMKB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  62
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-nitro-4-piperidin-1-yl-quinoline 在 吡啶 、 盐酸 、 tin(II) chloride dihdyrate 作用下， 以 乙醇 、 氯仿 、 水 为溶剂， 反应 5.5h， 生成 2-chloro-N-(4-(piperidin-1-yl)quinolin-8-yl)acetamide
  参考文献：
  名称：

  Substituent-dependent fluorescent sensors for zinc ions based on carboxamidoquinoline

  摘要：

  一系列基于羧酰胺喹啉的荧光传感器（AQZ家族）被合成并表征。AQZ家族成员在水中的溶解性很高，并通过在水中缓冲溶液中增强的荧光显示出对Zn²⁺的良好选择性。通过在喹啉环上引入不同的取代基，荧光信号可以在结合Zn²⁺时从双波长比率变化调整到单一波长强度的变化。使用这些传感器可以检测到10⁻⁵至10⁻⁶M的自由Zn²⁺浓度。取代基及其在喹啉环上的位置变化影响了它们对Zn²⁺的敏感性，但对Zn²⁺的亲和力影响不大。

  DOI：

  10.1039/c2dt31139a

文献信息

• Compositions and methods for modulating interaction between polypeptides
  申请人：Kazantsev G. Aleksey

  公开号：US20050239833A1

  公开（公告）日：2005-10-27

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.

  本发明部分基于我们所进行的检测，这些检测揭示了可用于治疗或预防以一种蛋白质与另一种蛋白质的异常或不良结合为特征的疾病的化合物。
• COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES
  申请人：The General Hospital Corporation

  公开号：US20130203733A1

  公开（公告）日：2013-08-08

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
• US8404747B2
  申请人：——

  公开号：US8404747B2

  公开（公告）日：2013-03-26
• [EN] COMPOSITIONS AND METHODS FOR MODULATING INTERACTION BETWEEN POLYPEPTIDES<br/>[FR] COMPOSITIONS ET PROCEDES POUR MODULER L'INTERACTION ENTRE DES POLYPEPTIDES
  申请人：GEN HOSPITAL CORP

  公开号：WO2005087217A1

  公开（公告）日：2005-09-22

  The present invention is based, in part, on assays we conducted that revealed compounds that may be used to treat or prevent diseases characterized by an abnormal or undesirable association of one protein with another.
• Substituent-dependent fluorescent sensors for zinc ions based on carboxamidoquinoline
  作者：Yu Zhang、Xiangfeng Guo、Lihua Jia、Shicheng Xu、Zhihui Xu、Libo Zheng、Xuhong Qian

  DOI：10.1039/c2dt31139a

  日期：——

  A series of carboxamidoquinoline-based fluorescent sensors (the AQZ family) were synthesized and characterized. The AQZ family members were highly soluble in water and showed good selectivity for Zn2+via enhanced fluorescence in aqueous buffer solution. Fluorescence signals could be tuned from dual-wavelength ratiometric changes to changes in the intensity of a single wavelength upon binding Zn2+ through the introduction of different substituents onto the quinoline ring. Concentrations of free Zn2+ of 10−5–10−6 M could be detected using the sensors. Changes of substituents and their positions on the quinoline ring influenced the sensitivity for Zn2+, but had little effect on Zn2+ affinities.

  一系列基于羧酰胺喹啉的荧光传感器（AQZ家族）被合成并表征。AQZ家族成员在水中的溶解性很高，并通过在水中缓冲溶液中增强的荧光显示出对Zn²⁺的良好选择性。通过在喹啉环上引入不同的取代基，荧光信号可以在结合Zn²⁺时从双波长比率变化调整到单一波长强度的变化。使用这些传感器可以检测到10⁻⁵至10⁻⁶M的自由Zn²⁺浓度。取代基及其在喹啉环上的位置变化影响了它们对Zn²⁺的敏感性，但对Zn²⁺的亲和力影响不大。