3-[(2E)-3-(2-chlorophenyl)prop-2-enoyl]-4,6-dimethylpyridin-2(1H)-one | 1137829-92-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 3-[(2E)-3-(2-chlorophenyl)prop-2-enoyl]-4,6-dimethylpyridin-2(1H)-one
• 英文别名: 3-[(E)-3-(2-chlorophenyl)prop-2-enoyl]-4,6-dimethyl-1H-pyridin-2-one
• CAS: 1137829-92-5
• 化学式: C₁₆H₁₄ClNO₂
• 分子量: 287.746
• InChiKey: RUIWMIOHQYLPEX-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-乙酰基-4,6-二甲基-2(1H)-吡啶酮 、 2-氯苯甲醛 在 氢氧化钾 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以68%的产率得到3-[(2E)-3-(2-chlorophenyl)prop-2-enoyl]-4,6-dimethylpyridin-2(1H)-one
  参考文献：
  名称：

  Synthesis of chalcones on the basis of Pyridin-2(1H)-one

  摘要：

  Pyridin-2(lffl-one der,vatives form chalcones in the Claisen-Schinidt condensation with aroinatic and heteroaromatic aldehydes in the presence of bases. For various aldehydes and pyriditiones, (out- main niethods arc developed. They allow expected chalcones to be prepared in the hiolicst yields.

  DOI：

  10.1134/s107036320806025x

文献信息

• Small molecule anti-scarring agents
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US10548911B2

  公开（公告）日：2020-02-04

  Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a recombinant gene that expresses a detectable expression product in a dose-dependent response to TGFβ, as well as methods of identifying a compound that inhibits TGFβ-mediated expression of the detectable expression product.

  公开了治疗有需要的患者纤维化的方法，包括向患者施用一定量的本文所确定的活性剂，该活性剂对抑制肌成纤维细胞的形成从而治疗纤维化具有治疗效果。还公开了一种重组细胞系，该细胞系包括以对TGFβ的剂量依赖性反应表达可检测表达产物的重组基因，以及鉴定抑制TGFβ介导的可检测表达产物表达的化合物的方法。
• SMALL MOLECULE ANTI-SCARRING AGENTS
  申请人：UNIVERSITY OF ROCHESTER

  公开号：US20170216332A1

  公开（公告）日：2017-08-03

  Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a recombinant gene that expresses a detectable expression product in a dose-dependent response to TGFβ, as well as methods of identifying a compound that inhibits TGFβ-mediated expression of the detectable expression product.
• [EN] SMALL MOLECULE ANTI-SCARRING AGENTS<br/>[FR] AGENTS ANTI-CICATRICES FORMÉS DE PETITES MOLÉCULES
  申请人：UNIV ROCHESTER

  公开号：WO2015195684A2

  公开（公告）日：2015-12-23

  Disclosed are methods of treating fibrosis in a patient in need thereof that includes administering to the patient an amount of an active agent, as identified herein, that is therapeutically effective to inhibit myofibroblast formation and thereby treat the fibrosis. Also disclosed is a recombinant cell line that includes a recombinant gene that expresses a detectable expression product in a dose-dependent response to TGFβ, as well as methods of identifying a compound that inhibits TGFβ,-mediated expression of the detectable expression product.
• Synthesis of chalcones on the basis of Pyridin-2(1H)-one
  作者：V. V. Kalashnikov、I. P. Kalashnikova、V. I. Shestov

  DOI：10.1134/s107036320806025x

  日期：2008.6

  Pyridin-2(lffl-one der,vatives form chalcones in the Claisen-Schinidt condensation with aroinatic and heteroaromatic aldehydes in the presence of bases. For various aldehydes and pyriditiones, (out- main niethods arc developed. They allow expected chalcones to be prepared in the hiolicst yields.