α,α-Diaethyl-β-propiolacton | 1955-43-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: α,α-Diaethyl-β-propiolacton
• 英文别名: α,α-Diethyl-β-propiolacton；2,2-Diaethyl-propiolacton；2,2-Diaethyl-propiolacton-(1,3)；2,2-Diaethyl-β-propiolacton；3,3-diethyl-oxetan-2-one；3,3-Diethyloxetan-2-one
• CAS: 1955-43-7
• 化学式: C₇H₁₂O₂
• 分子量: 128.171
• InChiKey: FQFQWTFNRFUWKM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α,α-Diaethyl-β-propiolacton 在 盐酸 、 溶剂黄146 作用下， 生成 2-Chlormethyl-2-ethyl-buttersaeure
  参考文献：
  名称：

  Auf das Zentralnervensystem wirkende Substanzen XXV。Reaktionen derα-substitutioniertenβ-LactoneII。Eine neue allgemeine合成α-取代基丙酸酯和衍生物衍生物

  摘要：

  盐酸和氢溴酸在环裂解下与α-单-和α，α-二取代的β-内酯反应，明确导致相应的α-单-或α，α-二取代的β-卤代丙酸。这些产品是制备新化合物的有趣原料，可以通过锌和甲酸还原为相应的丙酸。所描述的合成是一般的合成并且可以高收率进行。此外，已经观察到，新的α，α-二取代的β-卤代丙酸可以通过碱的作用或在中性或弱酸性介质中通过锌的作用而被转化为β-丙内酯。

  DOI：

  10.1002/hlca.19610440427

文献信息

• Thermoplastic moulding composition
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0079632A1

  公开（公告）日：1983-05-25

  A thermoplastic moulding composition having good low temperature properties in addition to low distortion at paint bake temperatures comprises the blend of a selectively hydrogenated monoalkenyl arene-conjugated diene block copolymer, a vinyl aromatic-α,β-unsaturated cyclic anhydride copolymer, and a thermoplastic polyester.

  一种热塑性模塑组合物除了在涂料烘烤温度下变形小之外，还具有良好的低温性能，该组合物由选择性氢化单烯烃-炔共轭二烯嵌段共聚物、乙烯基芳香族-α，β-不饱和环酐共聚物和热塑性聚酯混合而成。
• Poly(glycolic acid)/poly(oxyethylene)triblock copolymers and method of manufacturing the same
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0108933A1

  公开（公告）日：1984-05-23

  Poly(glycolic acid)poly(oxyethylene) ABA triblock copolymers having the following formula: wherein x ist about 37.5 to 47.5 and y is about 5 to 25, weight percent. The copolymers are useful for manufacturing fibers possessing a sufficiently low modulus of elasticity to permit their use as absorbable sutures having the requisite flexibility for use in monofilament form. A process of preparation involves purifying the hydroxyl-ended poly(oxyalkylene) and allowing it to react with glycolide to produce an ABA triblock copolymer of extrusion grade in which A represents a polyglycolic acid block and B represents a poly(oxyalkylene) block.

  具有下式的聚羟基乙酸聚氧乙烯 ABA 三嵌段共聚物： 其中 x 约为 37.5 至 47.5，y 约为 5 至 25，重量百分比。这种共聚物可用于制造具有足够低弹性模量的纤维，使其可用作可吸收缝合线，并具有以单丝形式使用所需的柔韧性。制备工艺包括纯化羟基端聚（氧烷基），使其与乙二醛反应生成挤出级 ABA 三嵌段共聚物，其中 A 代表聚羟基乙酸嵌段，B 代表聚（氧烷基）嵌段。
• Impact resistant polymeric compositions
  申请人：SHELL INTERNATIONALE RESEARCH MAATSCHAPPIJ B.V.

  公开号：EP0211467A2

  公开（公告）日：1987-02-25

  Impact resistant polymeric composition comprising a polyamide or a polyester and a thermally stable modified selectively hydrogenated high 1,2-content block copolymer wherein at least one acid compound is grafted to the block copolymer at a secondary or tertiary carbon position.

  抗冲击聚合物组合物，包括聚酰胺或聚酯和热稳定改性选择性氢化高 1,2 含量嵌段共聚物，其中至少有一种酸化合物在二级或三级碳位置接枝到嵌段共聚物上。
• Method for the preparation of a polymer lactide
  申请人：Purac Biochem B.V.

  公开号：EP0314245A1

  公开（公告）日：1989-05-03

  A polymer lactide is prepared by the polymerization of meso-3,6-­dimethyl-1,4-dioxane-2,5-dione or mesodilactide and, if desired, other monomers. The mesolactide monomer has preferably a free acid content of less than 1 meq/kg dilactide and is then polymerized in a manner known per se. The compositions containing polymesolactide obtained according to this process do not posses the typical characteristics of poly-DL-lactide, poly-D-lactide or poly-L-­lactide. A shorter degradation time of a substrate based on the present polymer is unofficial for several purposes. The present polymers have a good biocompatibility and are thus suited for bone plates, clamps and sutures and controlled release of biologically active compounds. The present polylactides and/or copolymers there­of have the benefit of a good biodegradability, biocompatibility, non-toxicity and non-mutagenicity.

  聚合物内酯是通过聚合介-3,6-二甲基-1,4-二氧六环-2,5-二酮或介内酯以及（如需要）其他单体而制备的。介十二内酯单体的游离酸含量最好小于 1 meq/kg 二内酯，然后以本身已知的方式进行聚合。根据该工艺得到的含有聚间甲内酯的组合物不具有聚-DL-内酯、聚-D-内酯或聚-L-内酯的典型特性。基于本聚合物的基质降解时间较短，这在几个方面都是非官方的。本聚合物具有良好的生物相容性，因此适用于骨板、夹具、缝合线和生物活性化合物的控释。本聚乳酸和/或其共聚物具有良好的生物降解性、生物相容性、无毒性和无突变性。
• Reduced friction coatings for articles in contact with human or animal tissues
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0558965A2

  公开（公告）日：1993-09-08

  Materials for medical or veterinary use such as surgical sutures are coated with a special bioabsorbable blockpolyetherester to reduce the friction with the tissue. This blockpolymer comprises a block derived from ε-caprolactone and a comonomer, preferably an α-hydroxycarboylic acid, and a poly(alkylene oxide) block. Also described are a film or a coating for a mesh, prepared from a bioabsorbable aliphatic blockpolyetherester, for use as an adhesion prevention barrier for mammalian tissue.

  用于医疗或兽医的材料，如手术缝合线，都涂有一种特殊的生物可吸收嵌段聚合物，以减少与组织的摩擦。 这种嵌段聚合物包括由 ε-己内酯和共聚单体（最好是 α-羟基卡波酰基酸）生成的嵌段以及聚环氧乙烷嵌段。 此外，还介绍了一种由生物可吸收脂肪族嵌段聚醚酯制备的薄膜或网状涂层，可用作哺乳动物组织的防粘连屏障。