4-[4'-(4''-hydroxybutoxy)phenyl]butyric acid | 912338-84-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[4'-(4''-hydroxybutoxy)phenyl]butyric acid
• 英文别名: 4-[4-(4-Hydroxybutoxy)phenyl]butanoic acid
• CAS: 912338-84-2
• 化学式: C₁₄H₂₀O₄
• 分子量: 252.31
• InChiKey: RHBVWFMFJVRWKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-[4'-(4''-hydroxybutoxy)phenyl]butyric acid 在 咪唑 、 dimethyl sulfide borane 、 2-碘酰基苯甲酸 作用下， 以 四氢呋喃 、 二氯甲烷 、 氯仿 、 二甲基亚砜 为溶剂， 反应 24.17h， 生成 N,N-dibenzyl-N-(4-{4'-[4''-(tert-butyldimethylsilanyloxy)butyl]phenoxy}butyl)amine
  参考文献：
  名称：

  Highly Chemoselective Formation of Aldehyde Enamines under Very Mild Reaction Conditions

  摘要：

  Although ketone enamines are widely used in organic synthesis, aldehyde enamines are rarely employed due to the limitations of their preparation using known methods (need for acid or base, excess of amine, and/or elevated temperature). We have successfully developed rapid and particularly mild condensation conditions (1 h, 0 degrees C, 1.2 equiv of amine) leading to di- and trisubstituted enamines with excellent conversion (84-100%). Remarkably high chemoselectivity was observed with complete discrimination between aldehyde and ketone, among other functional groups positively tested.

  DOI：

  10.1021/jo0611061
• 作为产物：
  描述：

  4-羟基苯丁酸甲酯 在 盐酸 、 potassium carbonate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 19.5h， 生成 4-[4'-(4''-hydroxybutoxy)phenyl]butyric acid
  参考文献：
  名称：

  Highly Chemoselective Formation of Aldehyde Enamines under Very Mild Reaction Conditions

  摘要：

  Although ketone enamines are widely used in organic synthesis, aldehyde enamines are rarely employed due to the limitations of their preparation using known methods (need for acid or base, excess of amine, and/or elevated temperature). We have successfully developed rapid and particularly mild condensation conditions (1 h, 0 degrees C, 1.2 equiv of amine) leading to di- and trisubstituted enamines with excellent conversion (84-100%). Remarkably high chemoselectivity was observed with complete discrimination between aldehyde and ketone, among other functional groups positively tested.

  DOI：

  10.1021/jo0611061

文献信息

• Highly Chemoselective Formation of Aldehyde Enamines under Very Mild Reaction Conditions
  作者：Guillaume Bélanger、Michaël Doré,、Frédéric Ménard、Véronique Darsigny

  DOI：10.1021/jo0611061

  日期：2006.9.1

  Although ketone enamines are widely used in organic synthesis, aldehyde enamines are rarely employed due to the limitations of their preparation using known methods (need for acid or base, excess of amine, and/or elevated temperature). We have successfully developed rapid and particularly mild condensation conditions (1 h, 0 degrees C, 1.2 equiv of amine) leading to di- and trisubstituted enamines with excellent conversion (84-100%). Remarkably high chemoselectivity was observed with complete discrimination between aldehyde and ketone, among other functional groups positively tested.