| 1454775-08-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• CAS: 1454775-08-6
• 化学式: C₂₀H₂₂N₆O₂S
• 分子量: 410.5
• InChiKey: UYQSFCDWMIBCMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  29.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  96.59
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  4-(丙-2-炔-1-基氧基)苯甲醛 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 甲醇 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 27.0h， 生成
  参考文献：
  名称：

  Evaluation of the Influence of thiosemicarbazone–triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents

  摘要：

  A series of thiosemicarbazone-triazole hybrids 1a-h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.08.028

文献信息

• Evaluation of the Influence of thiosemicarbazone–triazole hybrids on genes implicated in lipid oxidation and accumulation as potential anti-obesity agents
  作者：Henok H. Kinfe、Yonas H. Belay、Jitcy S. Joseph、Emmanuel Mukwevho

  DOI：10.1016/j.bmcl.2013.08.028

  日期：2013.10

  A series of thiosemicarbazone-triazole hybrids 1a-h are efficiently synthesised and evaluated for their influence on the expression of genes, cpt-1, acc-1 and pgc-1, which are essential in lipid metabolism. The test results show that hybrids 1c and 1g exhibited relatively high influence on the expression of cpt-1 and pgc-1 and suppression of acc-1 as desired. (C) 2013 Elsevier Ltd. All rights reserved.