2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-inino)methyl)phenol | 1224164-71-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-inino)methyl)phenol
• 英文别名: 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenol；HMQP；2-(Hydroxymethyl)-4-methyl-6-(quinolin-8-yliminomethyl)phenol
• CAS: 1224164-71-9
• 化学式: C₁₈H₁₆N₂O₂
• 分子量: 292.337
• InChiKey: CWRMMUKIMQIIDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  65.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  zinc perchlorate 、 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-inino)methyl)phenol 以 乙腈 为溶剂， 生成 Zn(2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenolate)2*H2O
  参考文献：
  名称：

  Both Visual and Fluorescent Sensor for Zn²⁺ Based on Quinoline Platform

  摘要：

  A fluorescent Zn2+ sensor 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenol (HMQP) based on the 8-aminoquinoline platform has been synthesized This sensor displays high selectivity, sensitive fluorescence enhancement, strong binding ability, and ratiometric response to Zn2+ in Tris-HCl (50 mM, pH 7 54), THF-H2O (9(.)1, v/v). And an obvious color change between HMQP and Zn2+-MQP(-) can be visually observed by the naked eye. The composition of the complex Zn2+-MQP(-) has been found lobe 1:2 based on the fluorescence/absorption titration and further confirmed by X-ray crystallography.

  DOI：

  10.1021/ic901354x
• 作为产物：
  描述：

  8-氨基喹啉 、 3-(羟基甲基)-5-甲基水杨醛 以 甲醇 为溶剂， 反应 4.0h， 以88%的产率得到2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-inino)methyl)phenol
  参考文献：
  名称：

  Both Visual and Fluorescent Sensor for Zn²⁺ Based on Quinoline Platform

  摘要：

  A fluorescent Zn2+ sensor 2-(hydroxymethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenol (HMQP) based on the 8-aminoquinoline platform has been synthesized This sensor displays high selectivity, sensitive fluorescence enhancement, strong binding ability, and ratiometric response to Zn2+ in Tris-HCl (50 mM, pH 7 54), THF-H2O (9(.)1, v/v). And an obvious color change between HMQP and Zn2+-MQP(-) can be visually observed by the naked eye. The composition of the complex Zn2+-MQP(-) has been found lobe 1:2 based on the fluorescence/absorption titration and further confirmed by X-ray crystallography.

  DOI：

  10.1021/ic901354x