3-[(tert-butoxycarbonyl)amino]-1,1,1-trifluoropentan-2-one | 219834-57-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(tert-butoxycarbonyl)amino]-1,1,1-trifluoropentan-2-one
• 英文别名: tert-butyl N-(1,1,1-trifluoro-2-oxopentan-3-yl)carbamate
• CAS: 219834-57-8
• 化学式: C₁₀H₁₆F₃NO₃
• 分子量: 255.237
• InChiKey: ZOEANMVMTYKNCN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  3-[(tert-butoxycarbonyl)amino]-1,1,1-trifluoropentan-2-one 在 palladium dihydroxide 氢气 、 对甲苯磺酸 作用下， 以 乙醇 、 水 、 乙酸乙酯 、 甲苯 为溶剂， 反应 3.0h， 生成 (S)-3-{2-[(S)-3-Benzyloxy-2-((S)-2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-acetylamino}-N-(1-ethyl-3,3,3-trifluoro-2-oxo-propyl)-succinamic acid benzyl ester
  参考文献：
  名称：

  Solid-Phase Synthesis of Peptidyl Trifluoromethyl Ketones

  摘要：

  DOI：

  10.1021/jo9815204
• 作为产物：
  描述：

  1,1,1-trifluoro-3-nitro-2-pentanol 在 镍 草酰氯 、 氢气 、 potassium carbonate 、 二甲基亚砜 、 三乙胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， -60.0 ℃ 、275.79 kPa 条件下， 反应 48.0h， 生成 3-[(tert-butoxycarbonyl)amino]-1,1,1-trifluoropentan-2-one
  参考文献：
  名称：

  Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease

  摘要：

  The development of peptidomimetic inhibitors of the human cytomegalovirus (HCMV) :protease showing sub-micromolar potency in an enzymatic assay is described. Selective substitution of the amino acid residues of these inhibitors led to the identification of tripeptide inhibitors showing improvements in inhibitor potency cf 27-fold relative to inhibitor 39 based upon the natural tetrapeptide sequence. Small side chains at P-1 were well tolerated by this enzyme, a fact consistent with previous observations. The S-2 binding pocket of HCMV protease was very permissive, tolerating lipophilic and basic residues. The substitutions tried at P-3 indicated that a small increase in inhibitor potency could be realized by the substitution of a tert-leucine residue for valine. Substitutions of the N-terminal capping group did not significantly affect inhibitor potency. Pentafluoroethyl ketones, alpha,alpha-difluoro-beta-keto amides, phosphonates and a-keto amides were all effective substitutions for the activated carbonyl component and gave inhibitors which were selective for HCMV protease. A slight increase in potency was observed by lengthening the P-1' residue of the alpha-keto amide series of inhibitors. This position also tolerated a variety of groups making this a potential site for future modifications which could modulate the physicochemical properties of these molecules.

  DOI：

  10.1021/jm970104t

文献信息

• Gold-Catalyzed Synthesis of Substituted 3-Trifluoromethylpyrroles from Mesylated Amino Trifluoromethylpropargylic Alcohols
  作者：Benjamin Guieu、Myriam Le Roch、Michèle David、Nicolas Gouault

  DOI：10.1021/acs.joc.7b02567

  日期：2017.12.15

  A series of substituted 3-trifluoromethylpyrroles was obtained from trifluoromethylamino-ynol derivatives via a gold-catalyzed cyclization. Using fluorinated starting materials, after mesylation, allowed for the desired compounds to be obtained in good yields under mild conditions.

  通过金催化的环化作用从三氟甲基氨基-炔醇衍生物获得一系列取代的3-三氟甲基吡咯。甲磺酸化后，使用氟化的起始原料，可以在温和的条件下以高收率获得所需的化合物。
• Peptidomimetic Inhibitors of the Human Cytomegalovirus Protease
  作者：William Ogilvie、Murray Bailey、Marc-André Poupart、Abraham、Amit Bhavsar、Pierre Bonneau、Josée Bordeleau、Yves Bousquet、Catherine Chabot、Jean-Simon Duceppe、Gulrez Fazal、Sylvie Goulet、Chantal Grand-Maître、Ingrid Guse、Ted Halmos、Pierre Lavallée、Michael Leach、Eric Malenfant、Jeff O'Meara、Raymond Plante、Céline Plouffe、Martin Poirier、François Soucy、Christiane Yoakim、Robert Déziel

  DOI：10.1021/jm970104t

  日期：1997.12.1

  The development of peptidomimetic inhibitors of the human cytomegalovirus (HCMV) :protease showing sub-micromolar potency in an enzymatic assay is described. Selective substitution of the amino acid residues of these inhibitors led to the identification of tripeptide inhibitors showing improvements in inhibitor potency cf 27-fold relative to inhibitor 39 based upon the natural tetrapeptide sequence. Small side chains at P-1 were well tolerated by this enzyme, a fact consistent with previous observations. The S-2 binding pocket of HCMV protease was very permissive, tolerating lipophilic and basic residues. The substitutions tried at P-3 indicated that a small increase in inhibitor potency could be realized by the substitution of a tert-leucine residue for valine. Substitutions of the N-terminal capping group did not significantly affect inhibitor potency. Pentafluoroethyl ketones, alpha,alpha-difluoro-beta-keto amides, phosphonates and a-keto amides were all effective substitutions for the activated carbonyl component and gave inhibitors which were selective for HCMV protease. A slight increase in potency was observed by lengthening the P-1' residue of the alpha-keto amide series of inhibitors. This position also tolerated a variety of groups making this a potential site for future modifications which could modulate the physicochemical properties of these molecules.
• Solid-Phase Synthesis of Peptidyl Trifluoromethyl Ketones
  作者：Marc-André Poupart、Gulrez Fazal、Sylvie Goulet、Ly Thy Mar

  DOI：10.1021/jo9815204

  日期：1999.2.1