5-[(benzyloxycarbonyl)aminomethyl]isophthalic acid | 323202-05-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-[(benzyloxycarbonyl)aminomethyl]isophthalic acid
• 英文别名: 5-[[[(Phenylmethoxy)carbonyl]amino]methyl]-1,3-benzenedicarboxylic acid；5-(phenylmethoxycarbonylaminomethyl)benzene-1,3-dicarboxylic acid
• CAS: 323202-05-7
• 化学式: C₁₇H₁₅NO₆
• 分子量: 329.309
• InChiKey: NZWHJNIVLPLQLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-[(benzyloxycarbonyl)aminomethyl]isophthalic acid 在 1,2-bis[(2S,5S)-2,5-diethylphospholano]benzene(1,5-cyclooctadiene)rhodium(I) trifluoromethanesulfonate lithium hydroxide 、 硼烷四氢呋喃络合物 、 Celite 、 氢气 、 pyridinium chlorochromate 、 四甲基胍 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 20.0 ℃ 、275.79 kPa 条件下， 反应 26.0h， 生成 (2S,2'S)-2,2'-bis(tert-butyloxycarbonylamino)-3,3'-{[(5-benzyloxycarbonylamino)methyl]-1,3-phenylene}bis(propanoic acid)
  参考文献：
  名称：

  Chiral, Polyionic Dendrimers with Complementary Charges − Synthesis and Chiroptical Properties

  摘要：

  Chiral dendrimers up to the second generation have been prepared from enantiopure aromatic bis- and tris(amino ac ids) by peptide coupling techniques. The dendrimers could be deprotected to yield water-soluble polyamine and/or polycarboxylic acid macromolecules. Two complementary types, with respect to the charges carried in water at pH = 7, were synthesised. A chiroptical study of the protected dendrimers, which were soluble in THF and CHCl3, was conducted. The results of that study indicate that the solution shapes of these dendrimers are rather decongested, with little steric interaction between different parts of the dendritic structure.

  DOI：

  10.1002/1099-0690(200011)2000:22<3771::aid-ejoc3771>3.0.co;2-1
• 作为产物：
  描述：

  5-氰基间苯二甲酸 、 氯甲酸苄酯 在 palladium on activated charcoal 盐酸 、 氢气 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 27.0h， 以73%的产率得到5-[(benzyloxycarbonyl)aminomethyl]isophthalic acid
  参考文献：
  名称：

  Chiral, Polyionic Dendrimers with Complementary Charges − Synthesis and Chiroptical Properties

  摘要：

  Chiral dendrimers up to the second generation have been prepared from enantiopure aromatic bis- and tris(amino ac ids) by peptide coupling techniques. The dendrimers could be deprotected to yield water-soluble polyamine and/or polycarboxylic acid macromolecules. Two complementary types, with respect to the charges carried in water at pH = 7, were synthesised. A chiroptical study of the protected dendrimers, which were soluble in THF and CHCl3, was conducted. The results of that study indicate that the solution shapes of these dendrimers are rather decongested, with little steric interaction between different parts of the dendritic structure.

  DOI：

  10.1002/1099-0690(200011)2000:22<3771::aid-ejoc3771>3.0.co;2-1

文献信息

• Catalytic Unfolding and Proteolysis of Cytochrome <i>c</i> Induced by Synthetic Binding Agents
  作者：Kevin Groves、Andrew J. Wilson、Andrew D. Hamilton

  DOI：10.1021/ja0317731

  日期：2004.10.1

  A class of polyanionic copper porphyrin dimers is shown to selectively increase the susceptibility of cytochrome c to proteolysis through binding-induced disruption of tertiary and secondary structure. The free energy of the protein conformation leading to proteolytic attack is stabilized by about 2.4 kcal/mol in the bound state. The proteolytic acceleration is catalytic in nature, requiring only a fraction of an equivalent of metalloporphyrin to effect complete, rapid digestion in the presence of a protease.
• Chiral, Polyionic Dendrimers with Complementary Charges − Synthesis and Chiroptical Properties
  作者：Andreas Ritzén、Torbjörn Frejd

  DOI：10.1002/1099-0690(200011)2000:22<3771::aid-ejoc3771>3.0.co;2-1

  日期：2000.11

  Chiral dendrimers up to the second generation have been prepared from enantiopure aromatic bis- and tris(amino ac ids) by peptide coupling techniques. The dendrimers could be deprotected to yield water-soluble polyamine and/or polycarboxylic acid macromolecules. Two complementary types, with respect to the charges carried in water at pH = 7, were synthesised. A chiroptical study of the protected dendrimers, which were soluble in THF and CHCl3, was conducted. The results of that study indicate that the solution shapes of these dendrimers are rather decongested, with little steric interaction between different parts of the dendritic structure.