Z-L-脯氨酸β-萘酰胺 | 86925-99-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: Z-L-脯氨酸β-萘酰胺
• 英文名称: Benzyloxycarbonyl-proline-β-naphthylamide
• 英文别名: (S)-1-benzyloxycarbonyl-N-(2-naphthyl)-2-pyrrolidinecarboxamide；(N-Benzyloxycarbonyl-L-prolin)-β-naphthylamid；1-benzyloxycarbonyl-L-proline-[2]naphthylamide；1-Benzyloxycarbonyl-L-prolin-[2]naphthylamid；Z-L-proline beta-naphthylamide；benzyl (2S)-2-(naphthalen-2-ylcarbamoyl)pyrrolidine-1-carboxylate
• CAS: 86925-99-7
• 化学式: C₂₃H₂₂N₂O₃
• 分子量: 374.439
• InChiKey: JNQYOPCQZVPOCL-NRFANRHFSA-N

物化性质

• 熔点：
  131 °C
• 沸点：
  622.5±55.0 °C(Predicted)
• 密度：
  1.287±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Z-L-脯氨酸β-萘酰胺 在 N-乙基哌啶 、 氢溴酸 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 12.17h， 生成 N-[(苄氧基)羰基]甘氨酰-N-2-萘基-L-脯氨酰胺
  参考文献：
  名称：

  Hauzer, Karel; Servitova, Linda; Barth, Tomislav, Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 4, p. 1139 - 1148

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苄氧羰基-L-脯氨酸 在 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 生成 Z-L-脯氨酸β-萘酰胺
  参考文献：
  名称：

  Hauzer, Karel; Servitova, Linda; Barth, Tomislav, Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 4, p. 1139 - 1148

  摘要：

  DOI：

文献信息

• Enzyme activities and pH tests for the determination of the risk of obstetric and gynecologic complications in samples of body fluids of women
  申请人：UNIBIO S.R.L.

  公开号：EP1528396A1

  公开（公告）日：2005-05-04

  The current invention describes a method for selecting a particular population of women having a risk of developing obstetric or gynecologic pathologies indicated as odds ratio (OR) value higher than 5.5, comprising the following steps in order: a) determination of the levels of sialidase by means of the procedure described in Cauci et al. Am J Obstet Gynecol 1998; 178; 511-5 and/or prolidase activity by means of the procedure described in Cauci et al. J Infect Dis 1998; 178; 1698-706 in samples of body fluid; b) determination of the pH value of said body fluid samples; c) selecting the samples having a sialidase value equal or above 5.0 nmol of methoxyphenol and/or a prolidase level equal or above 1500 mOD for prolidase and a pH ≥ 5.0. Consequently, this method gives the physician an efficient tool to decide whether or not to administer a pharmacological therapy to women at risk of severe adverse outcomes.

  本发明描述了一种选择特定妇女群体的方法，这些妇女患产科或妇科疾病的风险表示为几率比（OR）值高于5.5，该方法依次包括以下步骤： a) 通过 Cauci 等人，Am J Obstet Gynecol 1998; 178; 511-5 和/或 Cauci 等人，J Infect Dis 1998; 178; 1698-706 中描述的程序，测定体液样本中的葡萄糖苷酶水平； b) 确定所述体液样本的 pH 值； c) 挑选出硅糖苷酶值等于或高于 5.0 毫摩尔甲氧基苯酚和/或脯氨酸酶水平等于或高于 1500 毫摩尔脯氨酸酶且 pH 值≥5.0 的样本。 因此，这种方法为医生提供了一个有效的工具，以决定是否对有可能出现严重不良后果的妇女进行药物治疗。
• Enzymatic test for the determination of the risk of pathologies related to the presence of sialidase or prolidase activity in women body fluid samples
  申请人：——

  公开号：US20040219617A1

  公开（公告）日：2004-11-04

  The current invention describes a method for the determination of the risk of pathologies related to the presence of sialidase and/or prolidase activity in body fluid samples of women, comprising the following steps in order: a) determination of the levels of sialidase and/or prolidase activity in said sample of body fluid; b) comparison of said levels of sialidase and/or prolidase activity with ranges of prefixed values of said activity; c) calculation of the risk factor. This method resulted particularly efficient in permitting to obtain an accurate and reliable evaluation of the risk of pathologies related to the presence of sialidase and/or prolidase activity in samples of body fluid of women. Consequently, this method gives the physician an efficient tool to decide whether or not to administer a pharmacological therapy.

  本发明描述了一种测定与妇女体液样本中存在的葡萄糖苷酶和/或葡萄糖苷酶活性有关的病变风险的方法，该方法依次包括以下步骤： a) 确定所述体液样本中葡萄糖苷酶和/或脯氨酸酶活性的水平； b) 将所述硅氨酸酶和/或脯氨酸酶活性水平与所述活性的预设值范围进行比较； c) 计算风险系数。 这种方法特别有效，可以准确、可靠地评估与妇女体液样本中存在的葡萄糖苷酶和/或葡萄 糖苷酶活性有关的病变风险。因此，这种方法为医生提供了一种有效的工具，以决定是否进行药物治疗。
• Enantioselective Synthesis of Binaphthol Derivatives by Oxidative Coupling of Naphthol Derivatives Catalyzed by Chiral Diamine·Copper Complexes
  作者：Makoto Nakajima、Irie Miyoshi、Kumiko Kanayama、Shun-ichi Hashimoto、Masahiro Noji、Kenji Koga

  DOI：10.1021/jo981808t

  日期：1999.4.1

  A highly efficient process of aerobic oxidative coupling of 2-naphthol derivatives catalyzed by 1 mol % of Cu(OH)Cl.TMEDA has been developed, Enantioselective oxidative coupling of naphthols was achieved by the use of 10 mol % of chiral catalysts prepared from proline-derived diamines and cuprous chloride, affording the corresponding binaphthols in good enantioselectivities of up to 78% ee. The ester moiety at the 3-position of the substrate was found to be essential for the good asymmetric induction observed in the present coupling reaction.
• Folk; Burstone, Archives of Biochemistry, 1956, vol. 61, p. 257,258
  作者：Folk、Burstone

  DOI：——

  日期：——
• ASSAY FOR PROLINE IMINOPEPTIDASE AND OTHER HYDROLYTIC ACTIVITIES
  申请人：LITMUS CONCEPTS, INC.

  公开号：EP0791071B1

  公开（公告）日：1999-09-15