1-butynol-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1-4)-2,3,6-tri-O-acetyl-α-D-galactopyranoside | 1414786-64-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-butynol-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1-4)-2,3,6-tri-O-acetyl-α-D-galactopyranoside
• 英文别名: [(2R,3S,4S,5R,6R)-4,5-diacetyloxy-6-but-3-ynoxy-3-[(2R,3R,4S,5S,6R)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxyoxan-2-yl]methyl acetate
• CAS: 1414786-64-3
• 化学式: C₃₀H₄₀O₁₈
• 分子量: 688.637
• InChiKey: RLWCIRHTMXUCKH-NQXIBGIKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  48
• 可旋转键数：
  21
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  221
• 氢给体数：
  0
• 氢受体数：
  18

反应信息

• 作为反应物：
  描述：

  3-[2-[2-[2-(2-叠氮基乙氧基)乙氧基]乙氧基]乙氧基]丙酸 、 1-butynol-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1-4)-2,3,6-tri-O-acetyl-α-D-galactopyranoside 在 copper(ll) sulfate pentahydrate 、 sodium ascorbate 作用下， 以 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 0.67h， 以84%的产率得到4,7,10,13-tetraoxapentadecanoic acid triazol-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1-4)-2,3,6-tri-O-acetyl-α-D-galactopyranoside
  参考文献：
  名称：

  Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose binding

  摘要：

  A functional detection assay was developed for Escherichia coli secreted shiga-like toxin based on antibody capture and visualization with a multivalent galabiose ligand. It was possible to detect verotoxin in medically relevant E. coli samples in a dose dependent fashion. This method is a new step towards measuring functional protein levels in complex mixtures, which can be used for diagnostic purposes in a clinical setting. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.053
• 作为产物：
  描述：

  O-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyl)-(1->4)-2,3,6-tri-O-acetyl-D-galactopyranose 在 三氟甲磺酸三甲基硅酯 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 生成 1-butynol-2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl-(1-4)-2,3,6-tri-O-acetyl-α-D-galactopyranoside
  参考文献：
  名称：

  Functional assay for shiga-like toxin via detection by antibody capture and multivalent galabiose binding

  摘要：

  A functional detection assay was developed for Escherichia coli secreted shiga-like toxin based on antibody capture and visualization with a multivalent galabiose ligand. It was possible to detect verotoxin in medically relevant E. coli samples in a dose dependent fashion. This method is a new step towards measuring functional protein levels in complex mixtures, which can be used for diagnostic purposes in a clinical setting. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.10.053