aflatoxin M1 | 412340-54-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: aflatoxin M1
• 英文别名: Cyclopenta(c)furo(3',2':4,5)furo(2,3-h)(1)benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-；3-hydroxy-11-methoxy-6,8,19-trioxapentacyclo[10.7.0.02,9.03,7.013,17]nonadeca-1,4,9,11,13(17)-pentaene-16,18-dione
• CAS: 412340-54-6
• 化学式: C₁₇H₁₂O₇
• 分子量: 328.278
• InChiKey: MJBWDEQAUQTVKK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  91.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  aflatoxin M1 在 二甲基二环氧乙烷 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 2.0h， 生成 aflatoxin M1 8,9-epoxide
  参考文献：
  名称：

  Aflatoxin M1 8,9-Epoxide: Preparation and Mutagenic Activity

  摘要：

  Treatment of aflatoxin M(1) (AFM(1)) with dimethyldioxirane in an anhydrous mixture of CH2-Cl-2 and acetone afforded the corresponding aflatoxin M(1) 8,9-epoxide (AFM(1)-E) in practically quantitative yield. This highly reactive intermediate was identified by H-1 NMR and characterized by its neat conversion into the corresponding trans-methoxyhydrin derivative 1. The analysis of the H-1 NMR spectrum of the above epoxide revealed that one stereoisomer, which should be that with the exo configuration, was present as major component. The mutagenicities of AFM(1)-E, the parent mycotoxin (AFM(1)), aflatoxin B-1 (AFB(1)), and its epoxide (AFB(1)-E) were assessed by using a sensitive improved Ames test with the Salmonella typhimurium strain TA-100. AFM(1) and AFB(1) had specific mutagenic activities (SMA) of 13 and 121 revertants/ng, respectively, with S9 metabolic activation. AFM(1)-E was mutagenic with and without metabolic activation showing SMA of 13 and 12 revertants/ng, respectively. AFB(1)-E had a SMA of 42 and 29 revertants/ng, with and without S9 metabolic enzymes, respectively. These results suggest that the epoxidation of AFM(1) can constitute a major route accounting for the cytotoxic effects elicited by this mycotoxin and that AFM(1)-E is not as active as AFB(1)-E in reacting with the constituents of the mutagenicity assay.

  DOI：

  10.1021/tx00045a002
• 作为产物：
  描述：

  aflatoxin B1 在 barium dihydroxide 、 selenium(IV) oxide 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 水 、 乙酸酐 、 溶剂黄146 、 苯 为溶剂， 反应 38.0h， 生成 aflatoxin M1
  参考文献：
  名称：

  Chemical conversion of aflatoxin B1 to M1

  摘要：

  DOI：

  10.1016/s0031-9422(00)83156-8

文献信息

• Preservative and Additive for Food and Feed
  申请人：Carpenter Robert H.

  公开号：US20090117206A1

  公开（公告）日：2009-05-07

  A preservative and additive for food and feed. One aspect of the invention concerns various acidified clays and minerals as food or feed additive to kill, or inhibit the growth of, harmful microorganisms and to inactivate mycotoxins, such as aflatoxins, present as contaminants in human foods and animal feeds. Another aspect of the present invention relates to a clay of hydrated sodium calcium aluminosilicate with relatively uniform particle size distribution.

  一种食品和饲料的防腐剂和添加剂。发明的一个方面涉及各种酸化的粘土和矿物质作为食品或饲料添加剂，以杀灭或抑制有害微生物的生长，并且去除人类食品和动物饲料中的霉菌毒素，例如黄曲霉毒素。另一个方面涉及一种具有相对均匀颗粒大小分布的水合钠钙铝硅酸盐粘土。
• AFLATOXIN TEMPLATES, MOLECULARLY IMPRINTED POLYMERS, AND METHODS OF MAKING AND USING THE SAME
  申请人：Alltech, Inc.

  公开号：US20160221983A1

  公开（公告）日：2016-08-04

  Molecularly imprinted polymers (MIPs) are materials exhibiting molecular recognition of a target molecule. MIPs are synthesized in the presence of an aflatoxin template, a mimic to the targeted molecule, used as an imprint that is further washed away with suitable solvent after completion of the polymerization process, leaving a cavity in the polymer of the same stereochemistry, functionality and morphology to the template. When the MIP encounters an aflatoxin, the molecule is bound in the cavity with a receptor-like affinity.

  分子印迹聚合物（MIPs）是一种表现出对目标分子的分子识别的材料。MIPs在黄曲霉毒素模板的存在下合成，该模板是目标分子的模拟物，用作印迹，聚合过程完成后，用适当的溶剂清洗掉，留下聚合物中具有相同立体化学、功能和形态的空腔。当MIP遇到黄曲霉毒素时，分子会以受体般的亲和力结合在空腔中。
• PRESERVATIVE AND ADDITIVE FOR FOOD AND FEED
  申请人：Carpenter Robert H.

  公开号：US20160073662A1

  公开（公告）日：2016-03-17

  A preservative and additive for food and feed. One aspect of the invention concerns various acidified clays and minerals as food or feed additive to kill, or inhibit the growth of, harmful microorganisms and to inactivate mycotoxins, such as aflatoxins, present as contaminants in human foods and animal feeds. Another aspect of the present invention relates to a clay of hydrated sodium calcium aluminosilicate with relatively uniform particle size distribution.

  一种用于食品和饲料的防腐剂和添加剂。本发明的一个方面涉及酸化粘土和矿物质作为食品或饲料添加剂，用于杀灭或抑制有害微生物的生长并且失活霉菌毒素，如黄曲霉毒素，这些毒素是存在于人类食品和动物饲料中的污染物。本发明的另一个方面涉及一种具有相对均匀粒度分布的水合钠钙铝硅酸盐粘土。
• Immunoassay
  申请人：BOOTS-CELLTECH DIAGNOSTICS LIMITED

  公开号：EP0117648A2

  公开（公告）日：1984-09-05

  There is described an enzyme inhibitor labelled immunoassay for measuring the concentration of an analyte in a sample wherein the substrate for the enzyme forms at least a part of the sample. In a particular embodiment the sample comprises or consists of a milk sample and the inhibitor label is capable of inhibiting the activity of an enzyme capable of clotting milk. Examples are given of suitable inhibitors. The assay described may be used to measure the concentration of progestagens or oestrogens in milk using the techniques of heterogeneous or homogeneous enzyme inhibitor labelled immunoassay. The results of such an assay give an indication of the fertility of a milk producing domestic animal (e. g. a cow) and may be used to diagnose pregnancy of such an animal. Particular compounds for use in the assay are described, as is a kit of reagents for use in the assay.

  本发明描述了一种酶抑制剂标记免疫测定法，用于测量样品中分析物的浓度，其中酶的底物至少构成样品的一部分。在一个特定的实施方案中，样品包括或由牛奶样品组成，抑制剂标签能够抑制能够凝结牛奶的酶的活性。本文举例说明了合适的抑制剂。所述检测方法可用于使用异构或同构酶抑制剂标记免疫检测技术来测量牛奶中孕激素或雌激素的浓度。这种检测的结果可显示产奶家畜（如奶牛）的生育能力，并可用于诊断该家畜是否怀孕。本文介绍了用于该测定法的特定化合物，以及用于该测定法的试剂盒。
• Process for detection of aflatoxins
  申请人：BOSTON UNIVERSITY

  公开号：EP0196787A1

  公开（公告）日：1986-10-08

  An affinity matrix and a method for the detection of low molecular weight compositions such as aflatoxins are provided utilizing specific monoclonal IgM antibody having an affinity constant not less than about 1 x 109 liters per mole. Methods for the preparation and use of such affinity matrices are also given. The detection is rapid, accurate, reproducible, and allows for quantitative recovery of the composition of interest.

  本发明提供了一种亲和基质和一种检测黄曲霉毒素等低分子量成分的方法，该方法利用了亲和力常数不小于约 1 x 109 升/摩尔的特异性单克隆 IgM 抗体，还提供了制备和使用这种亲和基质的方法。 该检测方法快速、准确、可重复，并可定量回收相关成分。