ethyl (+/-)-(2R,3R)-2-bromo-3-hydroxy-5-phenylpentanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: ethyl (+/-)-(2R,3R)-2-bromo-3-hydroxy-5-phenylpentanoate
• 英文别名: (+/-)-erythro-2-bromo-3-hydroxy-5-phenyl-valeric acid ethyl ester；(+/-)-erythro-2-Brom-3-hydroxy-5-phenyl-valeriansaeure-aethylester；ethyl (2S,3S)-2-bromo-3-hydroxy-5-phenylpentanoate
• 化学式: C₁₃H₁₇BrO₃
• 分子量: 301.18
• InChiKey: ALSWBHKQWDLWLG-RYUDHWBXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  17
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  ethyl (+/-)-(2R,3R)-2-bromo-3-hydroxy-5-phenylpentanoate 在 sodium azide 作用下， 以 二甲基亚砜 为溶剂， 以84%的产率得到ethyl (2R,3S)-2-azido-3-hydroxy-5-phenylpentanoate
  参考文献：
  名称：

  Novel derivatives of 4,4' dithiobis-(3-aminobutane-1-1-sulfonates) and compositions comprising the same

  摘要：

  本发明涉及公式（1）的4,4'-二硫基双(3-氨基丁烷-1-磺酸酯)的衍生物，用于治疗和预防原发性和继发性动脉高血压。

  公开号：

  US20060205695A1
• 作为产物：
  描述：

  ethyl (2E)-5-phenylpent-2-enoate 在 dibromamine-T 作用下， 以 水 、 乙腈 为溶剂， 反应 0.17h， 以86%的产率得到ethyl (+/-)-(2R,3R)-2-bromo-3-hydroxy-5-phenylpentanoate
  参考文献：
  名称：

  一种简单高效的方法，从烯烃中选择性合成立体溴代邻苯二酚和烷氧基溴化物

  摘要：

  已经开发了非常快速有效的方法，用于直接从烯烃合成邻位溴代醇和烷氧基溴化物，而无需任何催化剂。反应是在CH 3 CN-水（4：1）或酒精中，使用N，N-二溴-对甲苯甲苯磺酰胺（TsNBr 2）作为溴化剂进行的。已经获得了优异的产率以及区域选择性和立体选择性。溴代醇是瞬间形成的，而烷氧基溴化物的形成则需要30-60分钟。

  DOI：

  10.1021/jo0600611

文献信息

• The impact of gender, body dimension and body composition on hand-grip strength in healthy children
  作者：A. Sartorio、C. L. Lafortuna、S. Pogliaghi、L. Trecate

  DOI：10.1007/bf03344033

  日期：2002.5

  Maximum hand-grip (HG) strength, body composition and main anthropometric variables were evaluated in 278 children with normal weight and growth, aged 5-15 yr divided into 3 age groups: group 1, age+/-SD: 7.6+/-0.9 yr 7.6+/-0.9 SD (Tanner stage 1); group 2, age: 10.8+/-0.7 yr (Tanner stage: 2-3); group 3, age: 1 3.2+/-0.9 yr (Tanner stage: 4-5). Weight, height, body surface area (BSA), BMI, percent body fat (BF) and fat free mass (FFM) increased progressively and significantly from the younger to the older age group. A significant difference between genders was detected only for BF and FFM, females having a higher fat mass and a lower FFM compared to males. Most children were right-handed (91%). In either genders, a curvilinear relation was detected between HG strength and age, with best fit for the dominant (d) hand given by the equations: dHG=5.891 *10(0.051 age), r(2)=0.986, p<0.001 in males and dHG=6.163 *10(0.045 age), r(2)=0.973, p<0.001 in females. The increase in HG strength after 11 yr appears to be steeper in males as compared with that found in females. In both d and non-dominant (nd) hand, a significant difference in HG strength was detected between males and females, the average difference being about 10% at all ages. For both genders, nd hand was significantly weaker than d hand in the older age groups (2 and 3), but not in the younger group 1. Age and gender-dependent differences in HG strength (but not differences between d and nd hand) disappear if HG strength is normalized for FFM. Thus, in general, dHG strength normalized for FFM resulted on average to be 0.67+/-0.11 kg/kg. A multiple linear regression analysis indicated that HG was positively correlated with BMI, BSA, stature, stature(2) and FFM (p<0.001 for all correlations) without differences between genders, while a negative correlation was found between HG strength and %BF. The most significant correlation was found between HG strength and FFM, without any significant difference between genders, so that the overall equation describing the line for the d hand was: dHG strength = 2.32+0.63 FFM, r(2)=0.72, p<0.001. In conclusion, the present study indicates that the age-dependent increase of HG strength as well as the between-gender differences are strongly related to changes of FFM values occurring during childhood. Moreover, the study provides a standard normative value of maximal HG strength for the healthy children population in Northern Italy.
• US7582797B2
  申请人：——

  公开号：US7582797B2

  公开（公告）日：2009-09-01
• A Simple and Efficient Method for Regioselective and Stereoselective Synthesis of Vicinal Bromohydrins and Alkoxybromides from an Olefin
  作者：Prodeep Phukan、Pranita Chakraborty、Dolly Kataki

  DOI：10.1021/jo0600611

  日期：2006.9.1

  very rapid and efficient method has been developed for the synthesis of vicinal bromohydrins and alkoxybromides directly from an olefin without any catalyst. The reaction was performed in CH3CN−water (4:1) or alcohol using N,N-dibromo-p-toluenesulfonamide (TsNBr2) as the brominating agent. Excellent yields and regio- and stereoselectivities have been obtained. Bromohydrins are formed instantaneously

  已经开发了非常快速有效的方法，用于直接从烯烃合成邻位溴代醇和烷氧基溴化物，而无需任何催化剂。反应是在CH 3 CN-水（4：1）或酒精中，使用N，N-二溴-对甲苯甲苯磺酰胺（TsNBr 2）作为溴化剂进行的。已经获得了优异的产率以及区域选择性和立体选择性。溴代醇是瞬间形成的，而烷氧基溴化物的形成则需要30-60分钟。
• Novel derivatives of 4,4' dithiobis-(3-aminobutane-1-1-sulfonates) and compositions comprising the same
  申请人：Roques Pierre Bernard

  公开号：US20060205695A1

  公开（公告）日：2006-09-14

  The invention relates to derivatives of 4,4′-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.

  本发明涉及公式（1）的4,4'-二硫基双(3-氨基丁烷-1-磺酸酯)的衍生物，用于治疗和预防原发性和继发性动脉高血压。