2'-benzyloxy-4'-chloroacetophenone | 76292-53-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2'-benzyloxy-4'-chloroacetophenone
• 英文别名: 1-(2-(Benzyloxy)-4-chlorophenyl)ethanone；1-(4-chloro-2-phenylmethoxyphenyl)ethanone
• CAS: 76292-53-0
• 化学式: C₁₅H₁₃ClO₂
• 分子量: 260.72
• InChiKey: NHHMMLDHQLKWKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2'-benzyloxy-4'-chloroacetophenone 在 selenium(IV) oxide 作用下， 以 戊醇 为溶剂， 反应 50.0h， 以51%的产率得到7-chloro-3',4'-ethylenedioxyflavone
  参考文献：
  名称：

  Chemistry of isoflavone heteroanalogs. 11. Benzodioxane analogs of chalcone, flavone, and isoflavone

  摘要：

  DOI：

  10.1007/bf00519934
• 作为产物：
  描述：

  4'-氯-2'-羟基苯乙酮 、 氯化苄 在 potassium carbonate 、 potassium iodide 作用下， 以 丙酮 为溶剂， 反应 16.0h， 以59%的产率得到2'-benzyloxy-4'-chloroacetophenone
  参考文献：
  名称：

  Synthesis and Pharmacological Evaluation of Chlorinated N-Alkyl-3- and -5-(2-hydroxyphenyl)pyrazoles as CB 1 Cannabinoid Ligands

  摘要：

  The syntheses of several new 3- and 5-(4-chloro-2-hydroxyphenyl)-5- and -3-(2,4-dichlorophenyl)-1-alkylpyrazoles are reported. These syntheses started from simple chlorophenols, 2,4-dichlorobenzaldehyde or ethyl 2,4-dichlorobenzoate in order to prepare pyrazoles bearing three and four chloro substituents in certain positions. The affinity of these compounds towards the CB1 type cannabinoids receptors was then evaluated in human brain tissues (frontal cortex). The results showed that some of the compounds exhibit affinity towards this kind of receptors in the micromolar range.

  DOI：

  10.1007/s00706-007-0676-4

文献信息

• US4265903A
  申请人：——

  公开号：US4265903A

  公开（公告）日：1981-05-05
• Chemistry of isoflavone heteroanalogs. 11. Benzodioxane analogs of chalcone, flavone, and isoflavone
  作者：V. P. Khilya、A. Aitmambetov、A. V. Turov、A. M. Kornilov、D. Litkei、T. Patonai

  DOI：10.1007/bf00519934

  日期：1986.2
• Synthesis and Pharmacological Evaluation of Chlorinated N-Alkyl-3- and -5-(2-hydroxyphenyl)pyrazoles as CB 1 Cannabinoid Ligands
  作者：Vera L. M. Silva、Artur M. S. Silva、Diana C. G. A. Pinto、Nadine Jagerovic、Luis F. Callado、José A. S. Cavaleiro、José Elguero

  DOI：10.1007/s00706-007-0676-4

  日期：2007.8

  The syntheses of several new 3- and 5-(4-chloro-2-hydroxyphenyl)-5- and -3-(2,4-dichlorophenyl)-1-alkylpyrazoles are reported. These syntheses started from simple chlorophenols, 2,4-dichlorobenzaldehyde or ethyl 2,4-dichlorobenzoate in order to prepare pyrazoles bearing three and four chloro substituents in certain positions. The affinity of these compounds towards the CB1 type cannabinoids receptors was then evaluated in human brain tissues (frontal cortex). The results showed that some of the compounds exhibit affinity towards this kind of receptors in the micromolar range.